Exploring shared triggers and potential etiopathogenesis between migraine and idiopathic/genetic epilepsy: Insights from a multicenter tertiary-based study

Basit Öğe Kaydı
dc.authorscopusid57208498318
dc.authorscopusid6506804957
dc.authorscopusid57201086467
dc.authorscopusid36702588300
dc.authorscopusid57221600440
dc.authorscopusid6602570293
dc.authorscopusid6701466585
dc.contributor.authorTürk B.G.
dc.contributor.authorYeni S.N.
dc.contributor.authorAtalar A.Ç.
dc.contributor.authorEkizoğlu E.
dc.contributor.authorGök D.K.
dc.contributor.authorBaykan B.
dc.contributor.authorÖzge A.
dc.date.accessioned2024-06-12T10:25:00Z
dc.date.available2024-06-12T10:25:00Z
dc.date.issued2024
dc.description.abstractIntroduction: Migraine and epilepsy are two episodic disorders that share common pathophysiological mechanisms. The aim of our research was to assess the possible shared etiopathogenesis by analyzing the relations of headache, and seizure triggers, based on information obtained from a national cohort surveying the headache characteristics of 809 patients who had been diagnosed with idiopathic/genetic epilepsy. Material and methods: Our study utilized data from a multi-center, nationwide investigation of headaches in 809 patients with idiopathic/genetic epilepsy. Out of these, 508 patients reported complaints related to any type of headache (333 Migraines, 175 Headaches of other types). In the initial phase of the study encompassing the entire sample of 809 epilepsy patients, differences in seizure triggers were assessed between the migraine group (n = 333) and the non-migraine group (n = 476). Additionally, the subsequent part of the study pertains to a subgroup of the entire patient group, namely those affected by all types of headaches (n = 508), and differences in headache triggers were assessed among migraine patients (n = 333) and those with other types of headaches (n = 175). Similar differences were observed between epilepsy patients with and without a family history of epilepsy. Results: The most frequently reported seizure triggers in all I/GE group (n = 809) were stress (23%), sleep deprivation (22%) and fatigue (18%), respectively. The most frequently reported headache triggers in migraine patients were stress (31%), sleep deprivation (28%), and noise (26%). The occurrence of menstruation-triggered seizures in individuals with migraine and I/GE was found to be considerably higher than those without migraine. The most common triggers for seizure and headache among the individuals with a positive family history of epilepsy were determined to be light stimuli and sleep deprivation. Conclusion: In conclusion, our study provides valuable insights into the overlapping triggers including sleep patterns, stress levels, and menstrual cycles, etc. and potential shared etiology of migraine and I/GE. Recognizing these connections may facilitate the development of more precise therapeutic strategies and underscore the significance of adopting a holistic, multidisciplinary approach to the management of these intricate neurological conditions. Further research is essential to explore in greater depth the shared mechanisms underpinning these associations and their implications for clinical practice. © 2024 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.clineuro.2024.108146
dc.identifier.issn0303-8467
dc.identifier.pmid38367542en_US
dc.identifier.scopus2-s2.0-85185264546en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2024.108146
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16143
dc.identifier.volume237en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofClinical Neurology and Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComorbidity; Genetic Generalized Epilepsy; Idiopathic Generalized Epilepsy; Migraine; Trigger Factorsen_US
dc.subjectAdult; Article; Clinical Observation; Clinical Practice; Cohort Analysis; Comorbidity; Controlled Study; Demographics; Epileptic Patient; Family History; Fatigue; Female; Follow Up; Genetic Generalized Epilepsy; Headache; Human; Idiopathic Generalized Epilepsy; Major Clinical Study; Male; Menstrual Cycle; Menstruation; Mental Performance; Migraine; Noise; Physiological Stress; Seizure; Sleep Deprivation; Sleep Pattern; Television Viewing; Video Game; Clinical Trial; Epilepsy; Genetics; Migraine; Multicenter Study; Epilepsy; Female; Headache; Humans; Migraine Disorders; Seizures; Sleep Deprivationen_US
dc.titleExploring shared triggers and potential etiopathogenesis between migraine and idiopathic/genetic epilepsy: Insights from a multicenter tertiary-based studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu