Atorvastatin causes regression of endometriotic implants in a rat model
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Endometriotic implants were induced surgically in female Wistar albino rats, which were randomly divided into three groups. The rats in group I (n = 10) and group II (n = 9) were given 2.5 mg/kg/day intraperitoneal and oral atorvastatin, respectively, for 28 days. Group III (n = 9) was given no medication (control). The mean volume and weight of explants in group I were significantly lower (both P < 0.05) compared with group III. Histopathological score of the implants was significantly tower in groups I and II, when compared with group III (P < 0.01 and P < 0.05, respectively). There were significant reductions in explant concentrations of vascular endothelial growth factor and matrix metalloproteinase 9 in group I (P < 0.01 and P < 0.001, respectively) and group II (both P < 0.01) compared with group III while staining due to tissue inhibitor of metalloproteinase 2 was significantly higher in group I (P < 0.01) and group II (P < 0.01) compared with group III. Moreover, explant concentration of superoxide dismutase was significantly increased in groups I and II compared with group III (both P < 0.05). In conclusion, atorvastatin causes significant regression of endometriotic implants in rats. Moreover, intraperitoneal atorvastatin seems to be more effective than oral atorvastatin. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Atorvastatin, Rat Endometriosis Model, Superoxide Dismutase, VEGF, MMP-9, TIMP-2, Endothelial Growth-Factor, Matrix Metalloproteinases, Tissue Inhibitor, Eutopic Endometrium, Estrogen-Receptor, Oxidative Stress, In-Vitro, Peritoneal, Expression, Explants
Kaynak
Reproductive Biomedicine Online
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
20
Sayı
2
