Rosiglitazone, an agonist of peroxisome proliferator-activated receptor-gamma, prevents contralateral testicular ischaemia-reperfusion injury in prepubertal rats

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorInan, Mustafa
dc.contributor.authorBasaran, Umit
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorKanter, Mehmet
dc.contributor.authorYalcin, Omer
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorTuran, Nesrin
dc.date.accessioned2024-06-12T11:00:24Z
dc.date.available2024-06-12T11:00:24Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstract1. Rosiglitazone plays a positive role in the reparation of ischaemia-reperfusion (I/R) injury in different tissues. Thus, we examined its biochemical and histological effects on the contralateral testes to determine whether exogenous rosiglitazone affords any protection against testicular damage. 2. Forty-eight prepubertal male Wistar-Albino rats were divided into six groups. Testicular torsion was created by rotating the right testis 720 degrees in a clockwise direction for 5 h in all groups except group I, which was the sham-control group. In group II, bilateral orchiectomy was performed following the torsion period. After detorsion both testes were removed in the fifth hour in group III and on the seventh day in group IV. In group V, one-shot rosiglitazone (4 mg/kg) was administered 40 min before detorsion and both testes were removed following the torsion period. In group VI, rosiglitazone was administered (4 mg/kg) 40 min before detorsion and for 7 days, and then both testes were harvested. The tissue levels of malondialdehyde (MDA) were measured and mean testicular biopsy score (MTBS) and mean seminiferous tubule diameter (MSTD) were examined. Immunoexpression of endothelial nitric oxide synthase (eNOS) in testes tissues was investigated by immunohistochemical studies. 3. In the contralateral testis, the MTBS and MSTD values of group VI were significantly higher than those in group IV. Immunohistochemically, mild eNOS immunostaining was present in the germ cells of the contralateral testes in group IV after I/R. In group VI, intense eNOS immunoreactivity was seen in the contralateral testes. 4. Rosiglitazone reduces contralateral testicular damage formed after unilateral testicular torsion and alleviates the oxidative events.en_US
dc.identifier.doi10.1111/j.1440-1681.2007.04594.x
dc.identifier.endpage461en_US
dc.identifier.issn0305-1870
dc.identifier.issue5-6en_US
dc.identifier.pmid17439415en_US
dc.identifier.scopus2-s2.0-33947628273en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2007.04594.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20818
dc.identifier.volume34en_US
dc.identifier.wosWOS:000245225900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofClinical And Experimental Pharmacology And Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.subjectIschaemia-Reperfusionen_US
dc.subjectLipid Peroxidationen_US
dc.subjectRosiglitazoneen_US
dc.subjectTestisen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectBlood-Flowen_US
dc.subjectPpar-Gammaen_US
dc.subjectTestisen_US
dc.subjectLigandsen_US
dc.subjectExpressionen_US
dc.subjectTissueen_US
dc.subjectJ(2)en_US
dc.titleRosiglitazone, an agonist of peroxisome proliferator-activated receptor-gamma, prevents contralateral testicular ischaemia-reperfusion injury in prepubertal ratsen_US
dc.typeArticleen_US

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