Investigation of the Relationship Between Genome Wide Association Studies-derived Polymorphisms and Differentiated Thyroid Cancer Risk in a Turkish Population

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dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036;
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.authorwosidDemir, Selma/A-1500-2018
dc.authorwosidOZEN, YASEMİN/AEW-9427-2022
dc.contributor.authorDemir, Selma
dc.contributor.authorGurkan, Hakan
dc.contributor.authorCelik, Mehmet
dc.contributor.authorSezer, Atakan
dc.contributor.authorEker, Damla
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:16:25Z
dc.date.available2024-06-12T11:16:25Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Thyroid cancer is the most common malignancy of endocrine system. Genome Wide Association Studies (GWAS) revealed a number of common variants associated with thyroid cancer risk. In this study, we aimed to investigate the association of these known variants with thyroid cancer risk in a Turkish population living in Trakya region. Methods: The study included 97 cases of differentiated thyroid cancer and 379 healthy controls. Real-Time Polymerase Chain Reaction (RT-PCR) method was used for the genotyping of rs965513, rs944289, rs966423 rs2439302 polymorphisms. Results: There was no statistically significant difference between patients and controls in terms of SNP genotype and allele frequencies. The distribution of cumulative genetic risk scores between patients and controls was also not significantly different. In the multiple logistic regression analysis (MLR), it was observed that the relationship of rs2439302 polymorphism GG genotype with thyroid cancer risk has a trend to be significant ((p = 0.067, 95%CI: 2.947 (0.928-9.357)). Conclusion: We suggest that the confirmation of the association of common variants with thyroid cancer in different populations will contribute to make a consensus on global risk alleles. The marginal significance of the association of rs2439302 with thyroid carcinoma risk shown in our study supports the need for functional studies on the role of this polymorphism in thyroid carcinoma.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TuBAP 2016/132]en_US
dc.description.sponsorshipThis study has been financially supported by the Trakya University Scientific Research Projects Unit (TuBAP 2016/132) .en_US
dc.identifier.doi10.12996/gmj.2021.123
dc.identifier.endpage553en_US
dc.identifier.issn2147-2092
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85116800769en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://doi.org/10.12996/gmj.2021.123
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24292
dc.identifier.volume32en_US
dc.identifier.wosWOS:000726736200009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid Carcinomaen_US
dc.subjectGWASen_US
dc.subjectGenetic Risken_US
dc.subjectSusceptibility Locien_US
dc.subjectGene Polymorphismen_US
dc.subjectCommon Variantsen_US
dc.subjectCarcinomaen_US
dc.titleInvestigation of the Relationship Between Genome Wide Association Studies-derived Polymorphisms and Differentiated Thyroid Cancer Risk in a Turkish Populationen_US
dc.typeArticleen_US

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