The association of gene polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 with ischemic stroke in Turkish subjects of Trakya Region

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dc.authorscopusid24767004000
dc.authorscopusid24068634800
dc.authorscopusid6506542810
dc.authorscopusid6507959144
dc.authorscopusid6603040523
dc.authorscopusid57170174900
dc.authorscopusid34879364500
dc.contributor.authorSipahi T.
dc.contributor.authorGüldiken B.
dc.contributor.authorGüldiken S.
dc.contributor.authorÜstünda? S.
dc.contributor.authorTurgut N.
dc.contributor.authorBudak M.
dc.contributor.authorCakina S.
dc.date.accessioned2024-06-12T10:28:49Z
dc.date.available2024-06-12T10:28:49Z
dc.date.issued2009
dc.description.abstractObjectives: The aim of this study was to investigate the frequency of ACE insertion/deletion (I/D) and AT1R (A1166C) gene polymorphisms in ischemic stroke patients in Trakya region and the relation between these gene polymorphisms and stroke subtypes and vascular risk factors. Patients and Methods: The study involved 162 patients with ischemic stroke and 146 control subjects. Ischemic stroke patients were divided into large and small vessel disease subgroups according to ORG 10172 in Acute Stroke Treatment TOAST criteria. The ACE I/D polymorphism was investigated using polymerase chain reaction (PCR), and the AT1R (A1166C) polymorphism was identified using PCR and restriction fragment length polymorphism (RFLP) assay. Results: The ACE I/D genotype distribution in patients (DD=34.0%, ID=50.0%, II=16.0%) did not differ from those in controls (DD=34.3%, ID=49.7%, II=16.1%). The AT1R A1166C genotype distribution in patients (AA=58.0%, CA=34.6%, CC=7.4%) did not significantly differ from those in controls (AA=60.1%, CA=35.7%, CC=4.2%). There was also no difference among the stroke subgroups regarding the distribution of ACE I/D and AT1R (A1166C) polymorphisms. Conclusion: Our results show that ACE I/D and AT1R (A1166C) gene polymorphisms were not genetic risk factors for ischemic stroke in subjects in Trakya region. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.en_US
dc.identifier.endpage8en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-70349090159en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17443
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAce I/D Gene Polymorphism; At1r (A1166c) Gene Polymorphism; Ischemic Stroke; Renin-Angiotensin Systemen_US
dc.subjectAngiotensin Receptor; Dipeptidyl Carboxypeptidase; Article; Blood Vessel Diameter; Cardiovascular Risk; Cerebrovascular Accident; Clinical Assessment; Controlled Study; Disease Association; Dna Polymorphism; Female; Genotype; Human; Major Clinical Study; Male; Polymerase Chain Reaction; Restriction Fragment Length Polymorphism; Turkey (Republic)en_US
dc.titleThe association of gene polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 with ischemic stroke in Turkish subjects of Trakya Regionen_US
dc.typeArticleen_US

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