Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures

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dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridÇavuşoğlu, Türker/0000-0001-7100-7080
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridCETIN UYANIKGIL, Emel Oyku/0000-0001-8822-9130
dc.authoridsolmaz, volkan/0000-0002-9045-2347
dc.authorwosidUyanikgil, Yigit/KIE-9628-2024
dc.authorwosidUyanikgil, Yigit/KIA-7025-2024
dc.authorwosidUyanikgil, Yigit/KLY-8722-2024
dc.authorwosidÇavuşoğlu, Türker/AAJ-9609-2020
dc.authorwosidUyanikgil, Yigit/M-2746-2019
dc.authorwosidCinar, Bilge Piri/AAA-5038-2021
dc.authorwosidCETIN UYANIKGIL, Emel Oyku/M-4400-2019
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorCavusoglu, Tuerker
dc.contributor.authorCinar, Bilge Piri
dc.contributor.authorCetin, Emel Oeykue
dc.contributor.authorSur, Halil YAñlmaz
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-06-12T11:01:36Z
dc.date.available2024-06-12T11:01:36Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVitamin D has various systemic effects on bone metabolism, modulation of the immune system, stabilization of the cell membrane, oxidative stress, inflammation, apoptosis, and various other hormones. Differing from active vitamin D, paricalcitol is a relatively safe VDR agonist due to its relatively few side effects. This study has investigated the anticonvulsant effect of paricalcitol in convulsions induced by pentylenetetrazole (PTZ). 36 male Sprague-Dawley rats were divided randomly into two groups: 18 for EEG recording (PTZ 35 mg/kg) and 18 for behavioral studies (PTZ 70 mg/kg). Forty-five minutes before the PTZ injection, both groups of rats were given 5 and 10 mu g/kg of paricalcitol i.p., respectively. Racine convulsion scores, first myoclonic jerk time, spike percentages, and antioxidant status were evaluated in the groups. Our results showed that the Racine's Convulsion Scale (RCS) score significantly dropped in the paricalcitol-treated group, analysis of the first myoclonic jerk (FMJ) latencies demonstrated a significantly longer latency in the paricalcitol-applied group, and spike percentages at EEG recordings significantly decreased with paricalcitol. Moreover, MDA levels were lower and SOD activity were higher in the 5 mu g/kg paricalcitol group compared to the saline group; these results were more prominent in 10 mu g/kg paricalcitol group. Our study has demonstrated that paricalcitol has protective effects on PTZ-induced convulsions. Based on the SOD and MDA levels in our study, these effects may result from the antioxidant characteristics of paricalcitol.en_US
dc.identifier.doi10.1007/s00210-016-1273-z
dc.identifier.endpage1122en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue10en_US
dc.identifier.pmid27438482en_US
dc.identifier.scopus2-s2.0-84979224958en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1117en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-016-1273-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20966
dc.identifier.volume389en_US
dc.identifier.wosWOS:000383665800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Epilepsy Modelen_US
dc.subjectPentylenetetrazolen_US
dc.subjectParicalcitolen_US
dc.subjectElectroencephalogramen_US
dc.subjectChemically-Induced Seizuresen_US
dc.subjectEarly-Life Seizuresen_US
dc.subjectVitamin-Den_US
dc.subjectActivationen_US
dc.subjectEpilepsyen_US
dc.subjectSystemen_US
dc.subjectHealthen_US
dc.subjectGeneen_US
dc.subjectMiceen_US
dc.titleInhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizuresen_US
dc.typeArticleen_US

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