Pre-therapy Iodine-131 Uptake Value as a Prediction Method for Metastatic Lymph Node Status in Patients with Differentiated Thyroid Carcinoma

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dc.authoridSoyluoglu, Selin/0000-0003-4473-7138
dc.contributor.authorAktas, Gul Ege
dc.contributor.authorDemir, Selin Soyluoglu
dc.contributor.authorUstun, Funda
dc.contributor.authorSarikaya, Ali
dc.contributor.authorAltun, Gulay Durmus
dc.date.accessioned2024-06-12T11:16:25Z
dc.date.available2024-06-12T11:16:25Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: We hypothesized that postoperative lymph node status would affect I-131 uptake (RIU) due to pathophysiological behavior of benign and malign thyroidal tissue. This retrospective study was designed to assess whether RIU would predict the presence of lymph node metastasis (LNM). Methods: Data for differentiated thyroid cancer patients who received postoperative I-131 therapy at our institution between 2013 and 2016 were reviewed. Age, histopathology, TSH, Tg, anti-Tg, 2 and 24 hour RIU (2-24RIU), ultrasonography, I-131 dose, scans were reviewed. Patients were divided into groups according to lymph node status. The Delta RIU was calculated (Delta RIU=24RIU-2RIU) to define different metabolic behavior of I-131. Patients were grouped according to Delta RIU to assess the sensitivity, specificity, negative/positive predictive values, accuracy of Delta RIU predicting LNM. Results: 198 patients (38 males/160 females, age: 47 +/- 14 years) who received mean: 118 +/- 27 mCi I-131 were enrolled in the study. There was no difference between ages, TSH level, 2RIU values and the I-131 therapy dose of patients with and without LNM. Tg, anti-Tg, 24RIU, Delta RIU values were higher in patients with LNM. Patients with Delta RIU >= 1% had higher Tg values (mean +/- std: 16.63 +/- 46.53 vs. 6.70 +/- 31.18, p: 0.04). When Delta RIU >= 1% was used for predicting LNM, sensitivity, specificity, positive, negative predictive values, diagnostic accuracy were, 66%, 72%, 64%, 74 %, and 70% respectively. Conclusion: RIU was evaluated to predict neck LN status in this study. The sensitivity and specificity were comparable with modalities which are commonly used for determination of LNM. In light of the results of this study, when a pre-therapy RIU increase in time is observed, carrying out further investigation protocols for LNM, would contribute to pre-therapy staging.en_US
dc.identifier.doi10.2174/1573405613666170607151048
dc.identifier.endpage446en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85051632756en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage438en_US
dc.identifier.urihttps://doi.org/10.2174/1573405613666170607151048
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24299
dc.identifier.volume13en_US
dc.identifier.wosWOS:000415813000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Medical Imaging Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThyroiden_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectRadioiodine Uptakeen_US
dc.subjectLymph Node Metastasisen_US
dc.subjectWhole Body Scanen_US
dc.subjectPre-Therapyen_US
dc.subjectPapillary Microcarcinomaen_US
dc.subjectCanceren_US
dc.subjectUltrasonographyen_US
dc.subjectDissectionen_US
dc.subjectManagementen_US
dc.subjectMetabolismen_US
dc.subjectDiagnosisen_US
dc.subjectPatternen_US
dc.subjectImpacten_US
dc.titlePre-therapy Iodine-131 Uptake Value as a Prediction Method for Metastatic Lymph Node Status in Patients with Differentiated Thyroid Carcinomaen_US
dc.typeArticleen_US

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