Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients

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dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorKabayel, Levent
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorOzkan, Hulya
dc.contributor.authorOkman Kilic, Tulay
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:08:33Z
dc.date.available2024-06-12T11:08:33Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: In this study, we investigated the association of migraine with the Variable Number of Tandem Repeats (VNTR), repeated as 27 base pair, gene polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) and the insertion/deletion of angiotensin converting enzyme (ACE) gene polymorphisms. Methods: One hundred and five migraine and ninety seven healthy female control subjects were enrolled in the study. The patients were subdivided as migraine with aura and without aura, and the frequency and severity of migraine headaches were recorded. The eNOS VNTR (eNOS 4 a/b) and ACE insertion/deletion gene polymorphisms (ACE I/D) were assessed by polymerase chain reactions. Results: The allele and genotype frequencies of eNOS 4 a/b gene polymorphism showed no difference between the migraine and control groups. The genotypic distribution of the ACE I/D gene polymorphism in the migraine group significantly differed from that in the control group. The DD and ID genotype increased the risk of migraine as much as 2.571 (95% CI-1.138-5.811) and 4.453 (95% CI-2.006-9.883) compared to the II genotype. The same increased risk sustained for both genotypes in the migraine with aura subgroup, but only the ID genotype remained as the risk factor in the migraine without aura subgroup (OR-3.750, 95% CI-1.493-9.420). No association of gene polymorphisms with migraine frequency and severity was observed. Conclusion: Our findings support the relationship between migraine and the ACE I/D gene polymorphism. However, no association was found between migraine and the eNOS 4 a/b gene polymorphism.en_US
dc.identifier.doi10.4274/npa.y6665
dc.identifier.endpage278en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue3en_US
dc.identifier.pmid28360555en_US
dc.identifier.scopus2-s2.0-84884575353en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.4274/npa.y6665
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22480
dc.identifier.volume50en_US
dc.identifier.wosWOS:000325969200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegien_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives Of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectNitric Oxide Synthaseen_US
dc.subjectAngiotensin Converting Enzymeen_US
dc.subjectInsertion Deletion Polymorphismen_US
dc.subjectRisk-Factoren_US
dc.subjectGlu298asp Polymorphismen_US
dc.subjectAceen_US
dc.subjectAssociationen_US
dc.subjectDiseaseen_US
dc.titleEndothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patientsen_US
dc.typeArticleen_US

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