Frequency and the effects of spondyloarthritis-spectrum disorders on the clinical course and management of Takayasu arteritis: an observational retrospective study

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dc.authoridDemirci Yıldırım, Tuba/0000-0003-3186-0591
dc.authoridAbacar, Kerem Yigit/0000-0002-7668-7924
dc.authorwosidDemirci Yıldırım, Tuba/GWQ-3054-2022
dc.contributor.authorAbacar, Kerem
dc.contributor.authorKaymaz-Tahra, Sema
dc.contributor.authorBayindir, Oezuen
dc.contributor.authorInce, Burak
dc.contributor.authorKutu, Muhammet Emin
dc.contributor.authorYazici, Ayten
dc.contributor.authorEdiboglu, Elif Durak
dc.date.accessioned2024-06-12T11:15:58Z
dc.date.available2024-06-12T11:15:58Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives Extravascular findings of Takayasu arteritis (TAK) often share features with the spondyloarthritis (SpA) spectrum of disorders. However, the characteristics of this overlap and its effect on the vascular manifestations of TAK are not fully known. Therefore, we aimed to investigate the frequency of SpA-related features in TAK patients. Material and methods In this observational retrospective study, 350 patients with TAK classified according to ACR 1990 criteria, from 12 tertiary rheumatology clinics, were included and evaluated for the presence of axSpA, IBD, or psoriasis. Demographic, clinical features, angiographic involvement patterns, disease activity, and treatments of TAK patients with or without SpA were analyzed. Results Mean age was 45.5 +/- 13.6 years and mean follow-up period was 76.1 +/- 65.9 months. Among 350 patients, 31 (8.8%) had at least one additional disease from the SpA spectrum, 8 had IBD, 8 had psoriasis, and 20 had features of axSpA. In the TAK-SpA group, TAK had significantly earlier disease onset, compared to TAK-without-SpA (p = 0.041). SpA-related symptoms generally preceded TAK symptoms. Biological treatments, mostly for active vasculitis, were higher in the TAK-SpA group (70.9%) compared to TAK-without-SpA (27.9%) (p < 0.001). Vascular involvements were similar in both. Conclusion Our study confirmed that diseases in the SpA spectrum are not rare in TAK. Vascular symptoms appeared earlier in such patients, and more aggressive therapy with biological agents was required in the TAK-SpA group, suggesting an association between TAK and SpA spectrum. Key Points center dot The pathogenesis of Takayasu arteritis is mediated by an MHC class I alelle (HLA-B*52), similar to spondyloarthritis-disorders. center dot Extravascular findings of Takayasu arteritis are in the spectrum of spondyloarthritis disease. center dot This frequent coexistence between Takayasu arteritis and spondyloarthritic disorders suggests a relationship rather than a coincidence.en_US
dc.identifier.doi10.1007/s10067-024-06939-y
dc.identifier.endpage1578en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue5en_US
dc.identifier.pmid38563865en_US
dc.identifier.scopus2-s2.0-85189366471en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1571en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-024-06939-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24147
dc.identifier.volume43en_US
dc.identifier.wosWOS:001195781700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTakayasu Arteritisen_US
dc.subjectSpondyloarthritisen_US
dc.subjectInflammatory Bowel Diseasesen_US
dc.subjectPsoriasisen_US
dc.subjectSacroiliitisen_US
dc.subjectExtravascular Findingsen_US
dc.subjectAnkylosing-Spondylitisen_US
dc.subjectSusceptibility Locien_US
dc.subjectInitial Validationen_US
dc.subjectDiseaseen_US
dc.subjectClassificationen_US
dc.subjectAssociationen_US
dc.subjectCriteriaen_US
dc.subjectIdentificationen_US
dc.titleFrequency and the effects of spondyloarthritis-spectrum disorders on the clinical course and management of Takayasu arteritis: an observational retrospective studyen_US
dc.typeArticleen_US

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