Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorKaraca, Turan
dc.date.accessioned2024-06-12T10:56:34Z
dc.date.available2024-06-12T10:56:34Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCurcumin has several biological functions particularly antioxidant and anti-inflammatory. The aims of this study are determination of the protective effects of curcumin on cisplatin-induced renal tubular cell apoptosis and related pathways in kidney. Eighteen male Wistar albino rats were randomly divided into three groups (n=6): the control, cisplatin (CP), and cisplatin+curcumin (CP+CUR). Acute renal damage was induced by single dose of cisplatin (7.5mg/kg) injected by intraperitoneally (i.p). The animals of curcumin-treated group were received daily 200mg/kg curcumin per os (po), starting from 2 days before the injection of cisplatin to the day of sacrifice. Forty-eight hours after cisplatin injection, samples of cardiac blood and kidneys were harvested from the animals. In this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), IL-6, IL-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (MDA) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, Fas, and Fas ligand (Fas-L)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). In a conclusion, this study suggests that curcumin has antiapoptotic effect against cisplatin nephrotoxicity, in addition to anti-inflammatory and antioxidant properties.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-ARDEB-SBAG-113S831]en_US
dc.description.sponsorshipThis work was supported by Scientific and Technological Research Council of Turkey (TUBITAK-ARDEB-SBAG-113S831).en_US
dc.identifier.doi10.1080/0886022X.2016.1229996
dc.identifier.endpage1748en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue10en_US
dc.identifier.pmid27758164en_US
dc.identifier.scopus2-s2.0-84992104300en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1741en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2016.1229996
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19843
dc.identifier.volume38en_US
dc.identifier.wosWOS:000392430900026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.subjectCurcuminen_US
dc.subjectApoptosisen_US
dc.subjectFasen_US
dc.subjectFas-Len_US
dc.subjectOxidative Stressen_US
dc.subjectEpithelial-Cellsen_US
dc.subjectActivationen_US
dc.subjectKidneyen_US
dc.subjectInjuryen_US
dc.subjectMechanismsen_US
dc.subjectProtectsen_US
dc.subjectP53en_US
dc.subjectInfiltrationen_US
dc.subjectMitochondriaen_US
dc.titleCurcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosisen_US
dc.typeArticleen_US

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