Follicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear features

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.contributor.authorCan, Nuray
dc.contributor.authorCelik, Mehmet
dc.contributor.authorSezer, Yavuz Atakan
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorAyturk, Semra
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:09:16Z
dc.date.available2024-06-12T11:09:16Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe newly proposed nomenclature and diagnostic criteria for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), could improve the consistency and accuracy of diagnosing this entity. Diagnosis of NIFTP requires evaluation of the complete tumor border or capsule. The presence of tumor invasion in follicular thyroid neoplasms with papillary-like nuclear features has been recently discussed by many authors. In this study, we examined the predictive value and association of follicular morphological characteristics with the tumor invasion. In addition, we analyzed the association between tumor encapsulation and molecular profile in EFVPTC/NIFTP cases. A total of 106 cases of FVPTC were included in the study. The tumors were grouped based on the presence of tumor capsule and characteristics of tumor border, as 1) completely encapsulated tumors without invasion, 2) encapsulated tumors with invasion, 3) infiltrative tumors without a capsule. Clinicopathological features, histomorphological features [ nuclear criteria, minor diagnostic features, follicles oriented perpendicular to tumor border/capsule (FOPBC)] and molecular alterations in BRAF, NRAS, and KRAS genes were evaluated. FOPBC were significantly more frequently seen in encapsulated tumors with invasion (p = 0.008). The nuclear features were not associated with the presence of encapsulation and characteristics of tumor border. BRAF mutation was more frequent in infiltrative tumors, while NRAS mutation was more frequent in encapsulated tumors, but the results were not statistically significant (p = 0.917). In conclusion, FOPBC histomorphological feature may be associated with tumor invasion in EFVPTC/NIFTP. Additionally, BRAF/KRAS/NRAS mutation analysis may prevent inadequate treatment in these patients.en_US
dc.identifier.doi10.17305/bjbms.2017.2039
dc.identifier.endpage220en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue3en_US
dc.identifier.pmid28453434en_US
dc.identifier.scopus2-s2.0-85028603900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2017.2039
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22752
dc.identifier.volume17en_US
dc.identifier.wosWOS:000410590500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNoninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Featuresen_US
dc.subjectNIFTPen_US
dc.subjectEFVPTCen_US
dc.subjectHistomorphological Featuresen_US
dc.subjectFollicular Variant Of Papillary Thyroid Carcinomaen_US
dc.subjectFVPTCen_US
dc.subjectNRASen_US
dc.subjectBRAFen_US
dc.subjectMutationen_US
dc.subjectLymph-Node Metastasisen_US
dc.subjectRas Mutationsen_US
dc.subjectCarcinomaen_US
dc.subjectVarianten_US
dc.subjectCanceren_US
dc.subjectBrafen_US
dc.subjectTumorsen_US
dc.subjectOvertreatmenten_US
dc.subjectPrevalenceen_US
dc.subjectLesionsen_US
dc.titleFollicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear featuresen_US
dc.typeArticleen_US

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