Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animals

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dc.authoridGürbüz, Murat/0000-0001-7778-7524
dc.authoridogut, serdal/0000-0001-8863-7249
dc.authorwosidGürbüz, Murat/ACQ-8389-2022
dc.authorwosidogut, serdal/IAL-9571-2023
dc.contributor.authorGurbuz, Murat
dc.contributor.authorOgut, Serdal
dc.date.accessioned2024-06-12T11:09:33Z
dc.date.available2024-06-12T11:09:33Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: recently, a relationship between diabetic complications and oxidative stress has been emphasized. There have been some studies showing the effect of olive leaf on hyperglycemia and diabetic complications due to its antioxidant properties. In many studies the effect of olive leaf on plasma total antioxidant level has been measured by different methods. Our study represents the first time it has been measured by a new method of total thiol disulfide homeostasis. Objective: chronic exposure to hyperglycemia and hyperlipidemia contributes to the pathogenesis of diabetic complications through oxidative stress mediators. Thiol is one of the most important antioxidant barriers in humans, and thiol disulfide homeostasis is a new oxidative stress marker. We aimed to investigate the effect of olive leaf extract (OLE) obtained from fresh leaves of Olea europaea, var oleaster on diabetic complications through their hypoglycemic and antioxidant effect in diabetic rats. Methods: twenty-eight Wistar albino rats aged 12-13 weeks were used in the study. The rats were divided into a control group (C), a diabetic control group pc), a diabetic group treated with 200 mg/kg OLE (D+200), and a diabetic group treated with 400 mg/kg OLE (D+400), having 7 rats in each group. The treatment groups received OLE by the gavage method for 21 days. At the end of the study, all rats were sacrificed by cervical dislocation. Blood samples collected from the heart were centrifuged and glucose, total cholesterol, triglyceride, urea, uric acid, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipid hydroperoxide (LOOH) level, and thiol-disulfide homeostasis were determined. The hemoglobin A1c (HbA1c) analysis was performed on complete blood. In addition, a tail flick test and hot plate modeling were performed to indicate pain perception loss. Results: it was observed that OLE had no effect on serum glucose and HbA1c levels. On the contrary, OLE reduced the levels of total cholesterol (p <0.01), urea (p <0.01) and hot plate latency (p < 0.01) in a significant manner. Also, OLE showed a tendency to reduce LOOH levels and to increase thiol levels in a dose-dependent manner (p > 0.05). Conclusion: OLE supplementation for 21 days, at the amounts used, cannot protect against hyperglycemia but may be protective against hypercholesterolemia and tissue damage as caused by diabetes mellitus in rats.en_US
dc.description.sponsorshipAdnan Menderes University Scientific Research Projects Unit [17004]en_US
dc.description.sponsorshipThis study was supported by the Adnan Menderes University Scientific Research Projects Unit, project number 17004.en_US
dc.identifier.doi10.20960/nh.03051
dc.identifier.endpage1021en_US
dc.identifier.issn0212-1611
dc.identifier.issn1699-5198
dc.identifier.issue5en_US
dc.identifier.pmid32960633en_US
dc.identifier.scopus2-s2.0-85093947452en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1012en_US
dc.identifier.urihttps://doi.org/10.20960/nh.03051
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22863
dc.identifier.volume37en_US
dc.identifier.wosWOS:000597951700018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAran Ediciones, S Len_US
dc.relation.ispartofNutricion Hospitalariaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOlive Leafen_US
dc.subjectOleuropeinen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectOlea Europaea L.en_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectOxidative Stressen_US
dc.subjectUric-Aciden_US
dc.subjectOleuropeinen_US
dc.subjectType-1en_US
dc.subjectRatsen_US
dc.subjectMechanismsen_US
dc.titleAntidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animalsen_US
dc.typeArticleen_US

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