Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

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dc.authoridAtesoglu, Elif Birtas/0000-0002-2596-4493
dc.authoridatalay, figen/0000-0003-4384-2913;
dc.authorwosidAtesoglu, Elif Birtas/G-5166-2018
dc.authorwosidatalay, figen/B-5507-2014
dc.authorwosidHacıhanefioğlu, Abdullah/G-1501-2018
dc.authorwosidTARKUN, PINAR/G-1478-2018
dc.contributor.authorAtesoglu, Elif Birtas
dc.contributor.authorTarkun, Pinar
dc.contributor.authorMehtap, Ozgur
dc.contributor.authorDemirsoy, Esra Terzi
dc.contributor.authorAtalay, Figen
dc.contributor.authorMaden, Muhammet
dc.contributor.authorCelebi, Koray
dc.date.accessioned2024-06-12T10:51:43Z
dc.date.available2024-06-12T10:51:43Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMolecular balance between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) has important effects in tumor angiogenesis. Ang-2 was shown to be elevated and proved to be a prognostic factor in acute myeloid leukemia (AML). To date studies revealed increased angiogenesis in bone marrows (BMs) of both myeloproliferative neoplasm (MPN) and AML patients. We conducted this study to demonstrate circulating levels of Ang-1 and Ang-2 in MPN patients since no data exists in literature. Thirty-three newly diagnosed MPN, 27 newly diagnosed AML patients and 25 controls (HC) were enrolled and Angiopoietin levels were determined with ELISA. We found that Ang-1 levels were higher whereas Ang-2 levels were lower in MPN and HC when compared to AML. Our results suggest that though angiogenesis is increased in both AML and MPN, angiopoietin serum level profile of the two diseases are different, and MPN patients have similar Ang-1 and Ang-2 levels as HC. We conclude that, according to our results Ang-1 and Ang-2 do not only regulate tumor angiogenesis and the difference between angiopoietin levels of acute and chronic myeloid neoplasms could be a reflection of other effects of these growth factors on tumor malignancy.en_US
dc.identifier.doi10.1007/s12288-015-0548-8
dc.identifier.endpage167en_US
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue2en_US
dc.identifier.pmid27065577en_US
dc.identifier.scopus2-s2.0-84961174052en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://doi.org/10.1007/s12288-015-0548-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18464
dc.identifier.volume32en_US
dc.identifier.wosWOS:000372248600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Hematology And Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiopoietin-1en_US
dc.subjectAngiopoietin-2en_US
dc.subjectAngiogenesisen_US
dc.subjectMyeloproliferative Neoplasmen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectMyeloproliferative Neoplasmsen_US
dc.subjectBone-Marrowen_US
dc.subjectExpressionen_US
dc.subjectGrowthen_US
dc.subjectVegfen_US
dc.titleSerum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesisen_US
dc.typeArticleen_US

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