Oxidative Stress and Testicular Torsion

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dc.contributor.authorDokmeci, Dikmen
dc.coverage.doi10.1007/978-1-61779-776-7
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTesticular torsion is a medical urologic syndrome that constitutes a surgical emergency affecting newborns, children, and adolescent boys. The main pathophysiological event in testicular torsion is ischemia (torsion) followed by reperfusion (detorsion) of the testis, and multifactorial mechanisms seem to mediate this condition. Testicular damage after ischemia/reperfusion (I/R) is related to the duration of ischemia and to the severity of the torsion. I/R injury is associated with activation of neutrophils, inflammatory cytokines, and adhesion molecules with increased thrombogenicity, release of massive intracellular calcium, and overgeneration of reactive oxygen species and reactive nitrogen species. Although the results are not conclusive and the molecular mechanism by which antioxidants control male fertility have not yet been clearly identified, several antioxidant enzymes and antioxidant drugs have been studied to prevent such I/R injury in testis. Antioxidant therapy may represent a new option within a broader therapeutic strategy in testicular torsion with oxidative stress-mediated infertility.en_US
dc.identifier.doi10.1007/978-1-61779-776-7_17
dc.identifier.endpage398en_US
dc.identifier.isbn978-1-61779-776-7
dc.identifier.isbn978-1-61779-775-0
dc.identifier.issn2197-7224
dc.identifier.issn2197-7232
dc.identifier.scopus2-s2.0-85026293293en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.1007/978-1-61779-776-7_17
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18592
dc.identifier.wosWOS:000303132700017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofStudies On Mens Health And Fertilityen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMale Infertilityen_US
dc.subjectOxidative Stressen_US
dc.subjectReactive Oxygen/Nitrogen Speciesen_US
dc.subjectTesticular Torsionen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectAntioxidant Enzyme-Activitiesen_US
dc.subjectActivated Protein-Kinasesen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectCell-Adhesion Moleculesen_US
dc.subjectTerm Histologic Damageen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectPhenethyl Ester Capeen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.titleOxidative Stress and Testicular Torsionen_US
dc.typeBook Chapteren_US

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