Elevated serum TNF-? levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorSayin, NC
dc.contributor.authorGücer, F
dc.contributor.authorBalkanli-Kaplan, P
dc.contributor.authorYüce, MA
dc.contributor.authorCiftci, S
dc.contributor.authorKücük, M
dc.contributor.authorYardim, T
dc.date.accessioned2024-06-12T11:16:27Z
dc.date.available2024-06-12T11:16:27Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: To compare the serum tumor necrosis factor-alpha (TNF-alpha) levels in nonobese women with those in women with polycystic ovaries (PCO) and polycystic ovary syndrome (PCOS) and healthy controls. STUDY DESIGN: Twenty-one sonographically and biochemically diagnosed women with PCOS, 19 with PCO and 14 healthy women were recruited for the study. Serum TNF-alpha levels were measured in all three groups. Insulin and glucose serum concentrations were analyzed before and after a 75-g oral glucose tolerance test in all samples. The serum TNF-alpha, glucose and insulin levels were compared in PCOS, PCO and controls. RESULTS: Serum TNF-alpha levels were similar in the PCOS and PCO groups (23.67 +/- 5.58 and 13.58 +/- 1.34 pg/mL, respectively) and significantly higher than in the control group. Serum TNF-alpha levels did not significantly correlated with body mass index, serum total testosterone, LH, DHEAS, fasting glucose and fasting insulin levels or glucose and insulin area under the curve values in the three groups. CONCLUSION: We found similar TNF-alpha levels in patients with PCOS and with PCO; however, there was no correlation between the TNF-alpha and insulin, glucose and androgen levels in the study.en_US
dc.identifier.endpage170en_US
dc.identifier.issn0024-7758
dc.identifier.issue3en_US
dc.identifier.pmid12698773en_US
dc.identifier.scopus2-s2.0-0037351505en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24324
dc.identifier.volume48en_US
dc.identifier.wosWOS:000181804500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal Of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTNF-Alphaen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectInsulinen_US
dc.subjectAndrogensen_US
dc.subjectNecrosis-Factor-Alphaen_US
dc.subjectImpaired Glucose-Toleranceen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectObese Patientsen_US
dc.subjectPrevalenceen_US
dc.subjectRisken_US
dc.subjectHyperandrogenismen_US
dc.subjectHyperinsulinemiaen_US
dc.subjectExpressionen_US
dc.titleElevated serum TNF-? levels in normal-weight women with polycystic ovaries or the polycystic ovary syndromeen_US
dc.typeArticleen_US

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