Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS?

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dc.authorscopusid6603260426
dc.authorscopusid7004330653
dc.authorscopusid15055232600
dc.authorscopusid12786699400
dc.authorscopusid24598133700
dc.contributor.authorSarikaya I.
dc.contributor.authorSarikaya A.
dc.contributor.authorAlbatineh A.N.
dc.contributor.authorTastekin E.
dc.contributor.authorSezer Y.A.
dc.date.accessioned2024-06-12T10:25:48Z
dc.date.available2024-06-12T10:25:48Z
dc.date.issued2020
dc.description.abstractObjective(s): Studies have reported that invasive ductal carcinoma (IDC) with coexisting ductal carcinoma in situ (DCIS) show lower metastatic potential and recurrence and better overall survival than pure IDC. In this study, we assessed F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images of patients with newly diagnosed IDC to determine if there is any difference in PET findings in IDC-DCIS and pure IDC cases. Methods: FDG PET/CT images of patients with newly diagnosed IDC of the breast who subsequently underwent breast surgery and had histopathology result in our records were further evaluated. Tumor grade, pathological staging, and presence of DCIS were noted from the histopathology results. Standardized uptake value (SUV) of the primary tumor (SUVmax and SULmax), other hypermetabolic foci in the breast, and ipsilateral normal breast were measured. Presence of axillary and distant metastases was noted. Results: Fifty seven (57) patients with IDC were included. Coexisting DCIS was present in 44 (IDC-DCIS) and not present in 13 (pure IDC) cases. Per histopathology, the primary tumor was unifocal in 33 IDC-DCIS (75%) and 12 pure IDC (92.3%) cases, and multifocal in 11 IDC-DCIS cases (25%), and 1 pure IDC case (7.7%). FDG uptake was multifocal in 20 IDC-DCIS cases (45.5%) and 1 pure IDC case (7.7%), and unifocal in 24 IDC-DCIS (54.5%), and 12 pure IDC (92.3%) cases. There was no significant difference in patient age, size of the primary tumor, SUVmax and SULmax of the primary tumor and SUVmax of the normal breast in IDC-DCIS and pure IDC cases (p>0.05). Pathology showed axillary metastasis in all 13 pure IDC (100%), and 27 IDC-DCIS (61.4%) cases. PET showed axillary uptake in 25 IDC-DCIS (56.8%), and 8 pure IDC (61.5%) cases, and abnormal/questionable distant uptake in 12 IDC-DCIS cases and 1 pure IDC case. Conclusion: In our preliminary findings, multifocal breast FDG uptake and multifocal tumor appear to be more common in IDC-DCIS than pure IDC. There is no significant difference in SUV and size of the primary tumor in IDC-DCIS and pure IDC cases. Axillary metastases appear to be more common in pure IDC than IDC-DCIS cases. © 2020 mums.ac.ir All rights reserved.en_US
dc.identifier.doi10.22038/aojnmb.2019.41658.1284
dc.identifier.endpage35en_US
dc.identifier.issn2322-5718
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85101307780en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.22038/aojnmb.2019.41658.1284
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16532
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMashhad University of Medical Sciencesen_US
dc.relation.ispartofAsia Oceania Journal of Nuclear Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Carcinoma; Coexisting Dcis; Fdg Pet; Invasive Ductal Carcinomaen_US
dc.titleIs there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS?en_US
dc.typeArticleen_US

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