THE EVALUATION OF RELATIONSHIP BETWEEN ERYTHROCYTE AND SERUM FERRITIN LEVELS WITH AMINOTRANSFERASE ENZYME LEVELS IN ANTI-HCV POSITIVE HEMODIALYSIS PATIENTS
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Istanbul Univ, Faculty Medicine, Publishing Office
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Serum ferritine level which is released from hepatocellular stores due to chronic inflammation of HCV infection, is accepted as an independent indicator of hepatocellular damage. It is not known whether intra- erythrocyte ferritin could be used as an indicator of hepatocellular damage as with serum ferritin, AST and ALT. In our study, we evaluated the relationship between aminotransferase level with eriythrocyte ferritin level and serum ferritin level in anti- HCV positive hemodialysis patients. Materials and methods: 40 HCV patients, taking hemodalysis therapy at five different hemodialysis center, were included in the study. They had no active inflamation, malignity and policytemia and had not been given blood transfusion. Erythrocyte and serum ferritin, ALT, AST, CRP, HBs- Ag, anti- HCV, anti- HIV levels were detected. The results were evaluated by using SPSS (ver. 12) statistics program. Results : 17 male and 23 female patients were taken to study and their average age was 54 +/- 16 year. Their alanineaminotransferase values were 25 +/- 29 IU/L, their aspartat aminotransferase values 20 +/- 12 IU/L, erythrocyte ferritin values 1.8 +/- 1.72 ng/gHb and their serum ferritin values were 992 +/- 424ng/ml. When the data evaluated, it was found that, there is a statistically significant positive correlation between the serum aminotransferase levels and the serum ferritin levels (p<0.05), whereas there was no statistically significant pozitif correlation between aminotransferase levels and erythrocyte ferritin levels (p>0.05). Conclusion: In HCV positive patients, AST, ALT and serum ferritin released from hepatoselluler stores shows liver damage. We found a significant positive correlation between aminotransferase levels and serum ferritin levels, but not with erythrocyte ferritin levels. This finding lead us to a conclusion that, erythrocyte ferritin levels are not a good marker for showing hepatocellular damage as like serum ferritin levels in HCV positive hemodialysis patients.
Açıklama
Anahtar Kelimeler
Erythrocyte Ferritin, Serum Ferritin, Alanineaminotransferase, Aspartate Aminotransferase
Kaynak
Journal Of Istanbul Faculty Of Medicine-Istanbul Tip Fakultesi Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
71
Sayı
1
