Incidence of antiheparin-platelet factor 4 antibodies and heparin-induced thrombocytopenia in Turkish patients undergoing cardiac surgery

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorDuran, Enver
dc.contributor.authorYigitbasi, Omer
dc.contributor.authorVural, Ozden
dc.contributor.authorKurum, Turhan
dc.contributor.authorYuksel, Mahmut
dc.contributor.authorTurgut, Burhan
dc.date.accessioned2024-06-12T11:03:07Z
dc.date.available2024-06-12T11:03:07Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe frequency of antiheparin-platelet factor 4 antibodies by means of antigenic and functional assays (C-14-serotonin release assay and citrated plasma platelet aggregation) was determined in 115 Turkish patients undergoing cardiac surgery. Blood samples were taken immediately before surgery and on days 5 and 10 +/- 2. Platelet counts were recorded and thrombotic events were determined by clinical methods. Antibody generation measured by enzyme-linked immunosorbent assay before surgery (n = 44) and on days 5 (n = 44) and 10 (n = 115) was 15.9%, 34.1%, and 65.2%, respectively. Positive samples from functional assays were 4.4% on day 0 and 7.0% on day 10. All positive samples had been negative on day 0. A high frequency of antiheparin-platelet factor 4 antibody generation and a low frequency of clinical heparin-induced thrombocytopenia were determined in these patients. These results obtained for Turkish patients are similar to those of other studies of heparin-induced thrombocytopenia.en_US
dc.identifier.doi10.1177/1076029607299987
dc.identifier.endpage284en_US
dc.identifier.issn1076-0296
dc.identifier.issue3en_US
dc.identifier.pmid17636189en_US
dc.identifier.scopus2-s2.0-34347236504en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.1177/1076029607299987
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21541
dc.identifier.volume13en_US
dc.identifier.wosWOS:000247675300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeparin-Induced Thrombocytopeniaen_US
dc.subjectCardiovascular Surgeryen_US
dc.subjectTurkish Cohorten_US
dc.subjectHeparinen_US
dc.subjectAntiheparin-Platelet Factor 4 Antibodiesen_US
dc.subjectCardiopulmonary Bypass-Surgeryen_US
dc.subjectDiagnostic Implicationsen_US
dc.subjectProspective Cohorten_US
dc.subjectPrevalenceen_US
dc.subjectThrombosisen_US
dc.titleIncidence of antiheparin-platelet factor 4 antibodies and heparin-induced thrombocytopenia in Turkish patients undergoing cardiac surgeryen_US
dc.typeArticleen_US

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