Involvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in mice

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridDost, Turhan/0000-0001-7547-3310
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidDost, Turhan/B-3088-2012
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorDost, T
dc.contributor.authorDokmeci, D
dc.contributor.authorAkpolat, M
dc.contributor.authorKaradag, CH
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:09:14Z
dc.date.available2024-06-12T11:09:14Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMorphine has long been known to have potent effects on body temperature. It has been suggested that both N-methl-D-aspartate (NMDA) receptors and nitric oxide (NO) pathway are involved in thermoregulation and also known to play important roles in some of morphine effects. The aim of this study was therefore to investigate the contribution of NMDA receptors and NO to the thermoregulatory effect of morphine. Morphine produced a hypothermic effect, especially at the dose of 10 mg/kg. Ketamine (5-40 mg/kg, i.p.) and N-G-nitro-L-arginine-methyl ester (L-Name, 1-100 mg/kg i.p.) also produced hypothermic effects with their higher doses. At doses which themselves produced no effect on colonic temperature in mice, both ketamine (10 mg/kg, i.p.) and L-NAME (10 mg/kg, i.p.) enhanced the hypothermic effect of morphine (10 mg/kg i.p.). These results further support the relationship between NO and NMDA receptors and suggest a possible role of NMDA-NO pathway in the thermoregulatory effect of morphine.en_US
dc.identifier.doi10.1007/s007020070074
dc.identifier.endpage521en_US
dc.identifier.issn0300-9564
dc.identifier.issue5en_US
dc.identifier.pmid11072747en_US
dc.identifier.scopus2-s2.0-0034059720en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage515en_US
dc.identifier.urihttps://doi.org/10.1007/s007020070074
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22735
dc.identifier.volume107en_US
dc.identifier.wosWOS:000086987900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Wienen_US
dc.relation.ispartofJournal Of Neural Transmissionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNMDAen_US
dc.subjectNitric Oxideen_US
dc.subjectMorphineen_US
dc.subjectHypothermiaen_US
dc.subjectCompetitive Antagonisten_US
dc.subjectPlace Preferenceen_US
dc.subjectNervous-Systemen_US
dc.subjectSpinal-Corden_US
dc.subjectRaten_US
dc.subjectInhibitionen_US
dc.subjectToleranceen_US
dc.subjectSynthaseen_US
dc.subjectInterleukin-1-Betaen_US
dc.subjectAcetylcholineen_US
dc.titleInvolvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in miceen_US
dc.typeArticleen_US

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