Synthesis of some benzocoumarin and benzochromone: Antielastase, antihyaluronidase, anticollagenase and antidiabetic activities and in silico ADME and molecular docking studies

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dc.authoridErtik, Onur/0000-0001-5437-3513
dc.authorwosidErtik, Onur/GWC-1868-2022
dc.contributor.authorErtik, Onur
dc.contributor.authorKolanc, Hakan
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCoumarins are compounds commonly found in nature and have many biological effects. So it is a molecule that continues to be popular. Benzocoumarin and benzochromone, which are coumarin derivatives, are a group of molecules obtained from plants and it is important to understand the biological activity of the derivatives of these molecules. In our study, the inhibitory effects of newly synthesized 9-hydroxy-1-methyl-3H-naphto[2,1-b]piran-3-on (benzocoumarin) (1) and 9-hydroxy-2-methyl-4H-naphto[2,1-b]piran-4-on (benzochromone) (2) on elastase, hyaluronidase, collagenase, alpha-amylase, and alpha-glucosidase were investigated. As a result of in vitro studies, the inhibition effect of compounds 1 (132.64 +/- 16.12 mu M) and 2 (400.25 +/- 64.77 mu M)), was observed relative to the dose, only the inhibition effect on collagenase was found to have a lower IC(50 )value than the positive control (479.03 +/- 38.40 mu M). In line with the data obtained as a result of in vitro studies, molecular docking studies were also carried out for compounds 1 and 2 with collagenase. As a result, due to the inhibitory effect of compounds 1 and 2 on the collagenase activity, a way has been opened for further studies to prove it.en_US
dc.identifier.doi10.56042/ijc.v63i3.5887
dc.identifier.endpage262en_US
dc.identifier.issn0019-5103
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85188896275en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.56042/ijc.v63i3.5887
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22010
dc.identifier.volume63en_US
dc.identifier.wosWOS:001188100600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication & Policy Research-Niscpren_US
dc.relation.ispartofIndian Journal Of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKeywords : Benzocoumarinen_US
dc.subjectBenzochromoneen_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectMolecular Dockingen_US
dc.subjectADMEen_US
dc.subjectAlpha-Glucosidaseen_US
dc.subjectCollagenaseen_US
dc.subjectExpressionen_US
dc.subjectAmylaseen_US
dc.titleSynthesis of some benzocoumarin and benzochromone: Antielastase, antihyaluronidase, anticollagenase and antidiabetic activities and in silico ADME and molecular docking studiesen_US
dc.typeArticleen_US

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