Fluoride related changes in behavioral outcomes may relate to increased serotonin

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dc.authoridNakano, Yukiko/0000-0002-1799-1205
dc.authoridmentes, ali/0000-0002-2778-6803
dc.authoridOnur, Şirin Güner/0000-0002-6890-3500
dc.authoridzheng, Jiaolin/0000-0002-6507-7071
dc.authoridabduweli uyghurturk, dawud/0000-0001-9389-3896
dc.authorwosidNakano, Yukiko/E-1019-2015
dc.authorwosidmentes, ali/HJZ-1125-2023
dc.authorwosidOnur, Şirin Güner/AAL-3712-2021
dc.contributor.authorLu, Fuxin
dc.contributor.authorZhang, Yan
dc.contributor.authorTrivedi, Alpa
dc.contributor.authorJiang, Xianging
dc.contributor.authorChandra, Dave
dc.contributor.authorZheng, Jiaolin
dc.contributor.authorNakano, Yukiko
dc.date.accessioned2024-06-12T11:19:58Z
dc.date.available2024-06-12T11:19:58Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFluoride ingestion has been linked to changes in behavior in mice and rats, related to dose, sex of the animal, and the timing of exposure. Previous studies have shown the behavior of female rats to be most affected by postnatal fluoride exposure, and in this study we determined the effects of postnatal fluoride exposure on anxiety related behavior and serotonin. Mice given 50 ppm fluoride in drinking water had increased entries in the open arms of the elevated plus maze, suggesting reduced anxiety. Both peripheral and central serotonin was increased in the fluoride treated mice. In a cohort of children drinking water containing 2.5 ppm fluoride, serum serotonin was also increased as compared to controls. The mechanisms by which fluoride results in an increase peripheral and central serotonin are not well understood, but warrant further study, as these effects may also be relevant to prenatal fluoride related changes in behavior in both mice and humans.en_US
dc.description.sponsorshipNIH/NIEHS [R21ES017813]; UCSF School of Dentistry; UCSF Center for Children's Oral Health Researchen_US
dc.description.sponsorshipThis project was supported by NIH/NIEHS R21ES017813 to PDB, Bridge funding from the UCSF School of Dentistry, and the UCSF Center for Children's Oral Health Research.en_US
dc.identifier.doi10.1016/j.physbeh.2019.02.017
dc.identifier.endpage83en_US
dc.identifier.issn0031-9384
dc.identifier.pmid30904570en_US
dc.identifier.scopus2-s2.0-85063425132en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2019.02.017
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25399
dc.identifier.volume206en_US
dc.identifier.wosWOS:000470050900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhysiology & Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSodium-Fluorideen_US
dc.subjectOxidative Stressen_US
dc.subjectHome Cageen_US
dc.subjectTransporteren_US
dc.subjectExposureen_US
dc.subjectNeurotoxicityen_US
dc.titleFluoride related changes in behavioral outcomes may relate to increased serotoninen_US
dc.typeArticleen_US

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