Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish population

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridCan, Guray/0000-0002-6054-9244
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidCAN, GÜRAY/AAA-3274-2020
dc.contributor.authorCan, Guray
dc.contributor.authorTezel, Ahmet
dc.contributor.authorGurkan, Hakan
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorUnsal, Gulbin
dc.contributor.authorSoylu, Ali Riza
dc.contributor.authorUmit, Hasan Celalettin
dc.date.accessioned2024-06-12T10:58:53Z
dc.date.available2024-06-12T10:58:53Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/Aims: Inflammatory bowel diseases are chronic, relapsing, inflammatory conditions. They have a genetic backround resulting in patient susceptibility. The aim of our study is to investigate the involvement of IL23R, JAK2, and STAT3 polymorphisms in inflammatory bowel diseases in a Turkish population. Materials and Methods: Polymorphisms in IL23R (rs11209026), JAK2 (rs10758669), and STAT3 (rs3816769, rs2293152, rs744166, rs957970, rs8074524) were genotyped in 69 Crohn's disease patients, 157 ulcerative colitis patients, and 89 healthy controls. Results: The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively). While rs2293152 (GC) was protective, rs2293152 (CC) increased the susceptibility to ulcerative colitis (p=0.009, p=0.001). All the polymorphisms were associated with age-at-diagnosis, except rs11209026. Furthermore, rs2293152 was associated with an extension in ulcerative colitis, while rs10758669, rs3816769, rs744166, rs2293152, and rs957970 were associated with the subphenotype in Crohn's disease. The presence of rs10758669 (AC) was protective against perianal Crohn's disease (p=0.016). Additionally, rs10758669 and rs2293152 in Crohn's disease and rs8074524, rs3816769, and rs10758669 in ulcerative colitis were associated with the requirement of immunsuppression. Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation. Conclusion: This is the first study of the single marker association of IL23R, JAK2, and STAT3 polymorphisms with ulcerative colitis and Crohn's disease in a Turkish population. It was demonstrated that these polymorphisms may be effective in the etiology of inflammatory bowel disease in this Turkish population.en_US
dc.description.sponsorshipScientific Investigation Support Committee of Trakya University (TUBAP), Edirne, Turkey [TUBAP-2013/107]en_US
dc.description.sponsorshipThis study was supported by fund from the Scientific Investigation Support Committee of Trakya University (TUBAP), Edirne, Turkey [TUBAP-2013/107].en_US
dc.identifier.doi10.5152/tjg.2016.16327
dc.identifier.endpage536en_US
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue6en_US
dc.identifier.pmid27852544en_US
dc.identifier.scopus2-s2.0-85014335846en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage525en_US
dc.identifier.trdizinid207359en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2016.16327
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/207359
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20227
dc.identifier.volume27en_US
dc.identifier.wosWOS:000388698100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrohn's Diseaseen_US
dc.subjectInterleukin-23 Receptoren_US
dc.subjectJanus Kinase-2en_US
dc.subjectSignal Transducer And Activator Of Transcription-3en_US
dc.subjectUlcerative Colitisen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectGenome-Wide Associationen_US
dc.subjectSingle Nucleotide Polymorphismsen_US
dc.subjectChinese Han Populationen_US
dc.subjectSusceptibility Locien_US
dc.subjectPathogenesisen_US
dc.subjectIl-23en_US
dc.subjectMetaanalysisen_US
dc.subjectReplicationen_US
dc.subjectMechanismsen_US
dc.titleInvestigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish populationen_US
dc.typeArticleen_US

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