Serum Leptin, Obestatin, and Ghrelin Levels and Gastric Emptying Rates of Liquid and Solid Meals in Non-obese Rats with Roux-en-Y Bypass Surgery or Prosthesis Placement: Implications for the Role of Vagal Afferents

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dc.authoridUniversity, Aydin Adnan Menderes/0000-0002-9325-3757
dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.authoridYegen, Berrak C./0000-0003-0791-0165
dc.authoridKUMRAL, Zarife Nigâr ÖZDEMİR/0000-0002-9485-0174
dc.authoridYegen, Cumhur/0000-0002-9231-0940
dc.authorwosidUniversity, Aydin Adnan Menderes/Z-2790-2019
dc.authorwosidYegen, Berrak/ABA-3274-2020
dc.authorwosidYegen, Berrak/O-6652-2017
dc.authorwosidYegen, Berrak C./ABA-1986-2020
dc.authorwosidKUMRAL, Zarife Nigâr ÖZDEMİR/AAG-1861-2020
dc.contributor.authorYavuz, Yunus
dc.contributor.authorKumral, Zarife Nigar Ozdemir
dc.contributor.authorMemi, Gulsun
dc.contributor.authorCevik, Ozge Dagdeviren
dc.contributor.authorYegen, Cumhur
dc.contributor.authorYegen, Berrak C.
dc.date.accessioned2024-06-12T11:13:46Z
dc.date.available2024-06-12T11:13:46Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. Methods Under anesthesia, male Sprague-Dawley rats underwent either sham operation, RYGB, prosthesis, and/or Gregory cannula placement. Three weeks later, liquid or solid gastric emptying tests were performed and serum ghrelin, leptin and obestatin levels were measured. Results Both prosthesis placement and RYGB surgery delayed non-nutrient liquid emptying; while solid nutrient emptying was delayed only by RYGB. Nutrient-dependent (acid, hyperosmolal and peptone) delay in liquid emptying was abolished in rats with prosthesis. By vagal afferent denervation, delayed liquid emptying was abolished, while solid emptying was further delayed in rats with prosthesis. Ghrelin and obestatin levels were depressed in prosthesis-placed rats, but RYGB surgery had no impact on both levels. Leptin level was elevated in solid-food-given rats with prosthesis, but not changed in RYGB group, while it was reduced following liquid meal. All the changes observed in ghrelin, obestatin, or leptin levels in response to meal ingestion were reversed with vagal afferent denervation. Conclusions Both RYGB and prosthesis placement had delaying effects on gastric emptying rate of non-obese rats. Our results indicate that the short-term changes in gastric motility and hormone responses induced by volume reduction are reversed by afferent denervation, suggesting that sparing the vagal innervation could be essential for reaching optimum motility and hormone changes expected after bariatric surgery.en_US
dc.description.sponsorshipMarmara University Research Funden_US
dc.description.sponsorshipThe authors acknowledge Merve Evren, PhD Candidate at Ege University Natural and Applied Sciences Department of Biotechnology, for the preparation of the excellent medical illustrations. This work was supported by a grant from Marmara University Research Fund.en_US
dc.identifier.doi10.1007/s11695-016-2420-9
dc.identifier.endpage1046en_US
dc.identifier.issn0960-8923
dc.identifier.issn1708-0428
dc.identifier.issue4en_US
dc.identifier.pmid27900560en_US
dc.identifier.scopus2-s2.0-85000443133en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1037en_US
dc.identifier.urihttps://doi.org/10.1007/s11695-016-2420-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23681
dc.identifier.volume27en_US
dc.identifier.wosWOS:000398070900028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRoux-En Y Bypassen_US
dc.subjectProsthesisen_US
dc.subjectVagal Afferentsen_US
dc.subjectLiquid Emptyingen_US
dc.subjectSolid Emptyingen_US
dc.subjectGregory Cannulaen_US
dc.subjectBody-Mass Indexen_US
dc.subjectSleeve Gastrectomyen_US
dc.subjectWeight-Lossen_US
dc.subjectIntragastric Balloonen_US
dc.subjectSurgical-Treatmenten_US
dc.subjectBariatric Surgeryen_US
dc.subjectMetabolic Surgeryen_US
dc.subjectPlasma Ghrelinen_US
dc.subjectObeseen_US
dc.subjectInhibitionen_US
dc.titleSerum Leptin, Obestatin, and Ghrelin Levels and Gastric Emptying Rates of Liquid and Solid Meals in Non-obese Rats with Roux-en-Y Bypass Surgery or Prosthesis Placement: Implications for the Role of Vagal Afferentsen_US
dc.typeArticleen_US

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