High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects

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dc.authoridOnaran, İlhan/0000-0003-4630-9516
dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authorwosidOnaran, Ilhan/C-8162-2019
dc.authorwosidOnaran, İlhan/AAH-9124-2019
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorOnaran, Ilhan
dc.contributor.authorAlici, Bulent
dc.contributor.authorOzkara, Hamdi
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorAkyolcu, Mehmet Can
dc.date.accessioned2024-06-12T10:55:28Z
dc.date.available2024-06-12T10:55:28Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description6th International Conference of the Balkan-Physical-Union -- AUG 22-26, 2006 -- Istanbul, TURKEYen_US
dc.description.abstractWe measured the levels of malondialdehyde (MDA), protein carbonyls, glutathione S-transferase (GST) and reducte glutathione (GSH) in seminal plasma and spermatozoa from 95 subjects including 50 infertile patients to evaluate the association between oxidative stress and damage and the components of the anti-oxidant defenses in seminal plasma and spermatozoa of infertile subjects and concentrations of cadmium (Cd) and lead (Pb) in the blood and seminal plasma because of tobacco smoke exposure. The reactive oxygen species (ROS) in spermatozoa were also evaluated by luminol (5-amino-2,3-dihydro-1,4-phthalazinedione)-enhanced chemiluminescence assay. The sperm count, motility, and morphology in the smokers infertile group were found to be lower than those in the fertile male group and nonsmokers infertile group (p < 0.001). Concentrations of Cd, Pb, MDA, protein carbonyls, and ROS levels in the smokers infertile group were significantly higher than those in the fertile male and nonsmokers infertile male groups (p < 0.001). However, GSH levels and GST activities were decreased in the smokers infertile male group than those in the fertile male and nonsmokers infertile male groups (p < 0.001). The results indicate that smoking could affect semen quality and oxidative lipid and protein damage in human spermatozoa. From Pearson correlation analysis, positive correlations were demonstrated between the seminal plasma Cd and seminal plasma protein carbonyls and between seminal plasma Pb and spermatozoa ROS levels in smokers of the subfertile group, while there was a significant positive correlation between blood Cd and ROS levels in smokers of the fertile group. There was also a significant negative correlation of the Cd level of the blood and GSH levels of the sperm and seminal plasma. These findings suggest that cigarette smoking enhances the levels of Cd and Pb in seminal plasma and blood and the extent of oxidative damage associated with a decrease in components of the anti-oxidant defenses in the sperm of infertile males.en_US
dc.description.sponsorshipBalkan Phys Union,Turkish Phys Soc,Istanbul Univ,Yildiz Tech Univ,Bogaz Univ,Dogus Univ,European Phys Soc,Govt Istanbul,Istanbul Metropolitan Municipal,Turkish Atomic Energy Author,Sci & Technol Res Council Turkey,United Natl Educ Sci & Cultutal Org,NEL Electroniken_US
dc.identifier.doi10.1007/s12011-007-8020-8
dc.identifier.endpage91en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1-3en_US
dc.identifier.pmid17916958en_US
dc.identifier.scopus2-s2.0-36048947277en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage82en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-007-8020-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19436
dc.identifier.volume120en_US
dc.identifier.wosWOS:000249916600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCadmiumen_US
dc.subjectLeaden_US
dc.subjectCigarette Smokingen_US
dc.subjectMale Infertilityen_US
dc.subjectSemen Analysisen_US
dc.subjectProtein Carbonylsen_US
dc.subjectMDAen_US
dc.subjectROSen_US
dc.subjectGSTen_US
dc.subjectGSHen_US
dc.subjectInduced Apoptosisen_US
dc.subjectSemen Parametersen_US
dc.subjectTrace-Elementsen_US
dc.subjectPlasmaen_US
dc.subjectSpermen_US
dc.subjectRaten_US
dc.subjectGlutathioneen_US
dc.subjectPopulationen_US
dc.subjectFertilityen_US
dc.subjectDnaen_US
dc.titleHigh levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjectsen_US
dc.typeConference Objecten_US

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