Determination of the Roles of Endothelial Nitric Oxide Synthase 4VNTR (4a/b), G894T, T786C Gene Variations in the Bladder Cancer Development

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dc.authoridÇevik, Gökhan/0000-0001-5221-5132
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidÇevik, Gökhan/GZA-3993-2022
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorCevik, Gokhan
dc.date.accessioned2024-06-12T10:54:46Z
dc.date.available2024-06-12T10:54:46Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the roles of eNOS gene variations in BCA development. Our study included 91 patients diagnosed with BCA and 91 healthy controls. eNOS 4VNTR (4a/b), T786C and G894T gene variations genotype distributions were determined by PCR and RFLP methods. The significant difference was determined between these groups in terms of eNOS T786C and eNOS G894T gene variations genotype distributions (p < 0.05). TT genotype for G894T gene variation and CC genotype for T786C gene variation were detected higher in patients. The CC genotype of T786C gene variation was detected significantly higher in male patients than in male controls (p < 0.05). In addition, aa-TT, ab-TT, bb-TT haplotypes of 4VNTR (4a/b)-G894T gene variations, aa-CC, ab-CC, bb-CC haplotypes of 4VNTR (4a/b)-T786C gene variations and TT-TT, TT-CC, TT-CT, GG-CC, GT-CC haplotypes of G894T-T786C gene variations were observed in patient group more than control group. The significant difference was detected between these groups in terms of eNOS (G894T-T786C) haplotypes (p < 0.05). In our study, eNOS T786C and eNOS G894T gene variations were determined important genetic risk factor in the Thrace population of Turkey.en_US
dc.identifier.doi10.1007/s12291-022-01090-4
dc.identifier.endpage100en_US
dc.identifier.issn0970-1915
dc.identifier.issn0974-0422
dc.identifier.issue1en_US
dc.identifier.pmid38223012en_US
dc.identifier.scopus2-s2.0-85139666728en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1007/s12291-022-01090-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19177
dc.identifier.volume39en_US
dc.identifier.wosWOS:000865196100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Canceren_US
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.subjectGene Variationsen_US
dc.subjectPCRen_US
dc.subjectRFLPen_US
dc.subjectRisken_US
dc.subjectPolymorphismsen_US
dc.subjectGlu298aspen_US
dc.subjectProgressionen_US
dc.subjectVarianten_US
dc.titleDetermination of the Roles of Endothelial Nitric Oxide Synthase 4VNTR (4a/b), G894T, T786C Gene Variations in the Bladder Cancer Developmenten_US
dc.typeArticleen_US

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