Over expressions of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in human uterine cervical neoplasms enhance tumor invasion

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dc.authorscopusid56543270000
dc.authorscopusid55909719300
dc.authorscopusid7801641142
dc.authorscopusid57190817443
dc.authorscopusid36561158700
dc.authorscopusid55376521200
dc.authorscopusid14047025900
dc.contributor.authorKahraman D.S.
dc.contributor.authorDiniz G.
dc.contributor.authorSayhan S.
dc.contributor.authorErsavas S.
dc.contributor.authorAyaz D.
dc.contributor.authorKeskin E.
dc.contributor.authorGulhan I.
dc.date.accessioned2024-06-12T10:25:57Z
dc.date.available2024-06-12T10:25:57Z
dc.date.issued2021
dc.description.abstractObjective: Accumulating evidence has demonstrated upregulation of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in multiple malignancies which play a critical role in tumor progression. However, up to now little is known about the role played by NGAL in human uterine cervical carcinomas. In this retrospective study we aimed to evaluate the role of tissue expressions of NGAL and KIM-1 in a spectrum of uterine invasive and noninvasive cervical neoplasms. Methods: Immunohistochemical NGAL and KIM-1 expressions were investigated in a total of 107 formalin-fixed, paraffin-embedded uterine cervical tumor specimens and their association with different clinicopathologic parameters was evaluated. Results: In this series, cases with 30 low- and 29 high- grade cervical squamous intraepithelial lesion (SIL), 27 squamous cell carcinoma (SCC), 15 adenosquamous carcinoma (ASC) and 6 adenocarcinoma (ACs) were detected. Positive NGAL expression was detected in only inflammatory cells of cases, whereas KIM-1 expression was detected in tumor cells. Statistically it was determined that the positivity rate of strong NGAL and KIM-1 expression was prominently higher in invasive carcinomas when compared with non-invasive squamous cell neoplasms (P < 0.01). KIM-1 expressions were not detected in any of the few cases with adenocarcinoma. Conclusion: Our findings have showed the presence of a correlation between membranous and cytoplasmic expressions of NGAL and KIM-1 and the invasive characteristics of uterine cervical neoplasms. As a result, expressions of NGAL and KIM-1 may be important in foreseeing the invasion and tumor progression. © 2021 The Authors. Published by IMR Press.en_US
dc.identifier.doi10.31083/j.ejgo.2021.01.2195
dc.identifier.endpage153en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85101074609en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.31083/j.ejgo.2021.01.2195
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16583
dc.identifier.volume42en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIMR Press Limiteden_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenocarcinoma; Adenosquamous Carcinoma; High- Grade Squamous Intraepithelial Lesions; Kim-1; Low- Grade Squamous Intraepithelial Lesions; Ngal; Squamous Cell Carcinoma; Uterine Cervixen_US
dc.subjectHepatitis A Virus Cellular Receptor 1; Neutrophil Gelatinase Associated Lipocalin; Adenosquamous Carcinoma; Adult; Aged; Article; Cancer Grading; Female; Gene Overexpression; Histopathology; Human; Human Tissue; Immunohistochemistry; Inflammatory Cell; Invasive Carcinoma; Major Clinical Study; Protein Expression; Retrospective Study; Tumor Growth; Tumor Invasion; Upregulation; Uterine Cervix Adenocarcinoma; Uterine Cervix Carcinoma; Uterine Cervix Carcinoma In Situ; Uterine Cervix Tumoren_US
dc.titleOver expressions of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in human uterine cervical neoplasms enhance tumor invasionen_US
dc.typeArticleen_US

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