The importance of weight loss during definitive radiotherapy in patients with laryngeal carcinoma

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dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorCaloglu, Murat
dc.contributor.authorTurkkan, Gorkem
dc.date.accessioned2024-06-12T11:07:28Z
dc.date.available2024-06-12T11:07:28Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to determine the prognostic significance of weight loss (WL) on overall survival (OS) and progression-free survival (PFS) in patients with locally advanced unresectable laryngeal carcinoma undergoing definitive radiotherapy (RT) or chemo-RT (CRT) in a single institution. Patients and Methods: One hundred and thirty-two patients with newly diagnosed locally advanced laryngeal carcinoma were included in this study retrospectively. All patients were treated with definitive RT or CRT. The tumor and metastatic lymph nodes received 70 Gy. Subclinical disease (low-risk and high-risk area) was irradiated 50-60 Gy prophylactically. Unintentional WL >= 5% was defined as the critical level. Bodyweight was evaluated on the 1st day of RT and once a week during RT. Caloric needs were calculated as 25-30 kcal/kg/day. Results: Median follow-up was 17.8 months (range: 2.35-85 months). During treatment, there was a statistically significant WL in patients (P = 0.004). WL was >= 5% in 62 (47%) of the patients. There was a statistically significant relationship between WL and tumor differentiation (P = 0.004), completion of treatment (P = 0.004), WHO performance status (P < 0.0001), T stage (P = 0.003), N stage (P = 0.049), and supraglottic tumor location (P = 0.005). In the univariate analysis, WL, WHO performance status, T stage, N stage, tumor localization, and tumor differentiation, were seen to affect OS. Additionally, WL, WHO performance status, N stage, and tumor differentiation were prognostic factors for PFS. In the multivariate analysis, it was observed that only WL and WHO performance status were significant factors for both OS (P = 0.001, and P < 0.01) and PFS (P < 0.001, and P < 0.001), respectively. Three-year OS and PFS was 50.3% and 19.5% for patients with WL versus 77.8% and 49.0% for patients without WL. Conclusions: It is clear that WL has prognostic significance in patients who have undergone definitive RT or CRT due to locally advanced laryngeal carcinoma. In particular, it should be taken into consideration that patients with supraglottic tumor, lymph node involvement, and poor performance status are at greater risk for WL.en_US
dc.identifier.doi10.4103/jcrt.JCRT_727_20
dc.identifier.endpage643en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue3en_US
dc.identifier.pmid35900534en_US
dc.identifier.scopus2-s2.0-85135202143en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage638en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_727_20
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22059
dc.identifier.volume18en_US
dc.identifier.wosWOS:000891771400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLaryngeal Carcinomaen_US
dc.subjectRadiotherapyen_US
dc.subjectWeight Lossen_US
dc.subjectNeck-Cancer Patientsen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectHeaden_US
dc.subjectChemoradiationen_US
dc.subjectNutritionen_US
dc.subjectSurvivalen_US
dc.subjectPredictorsen_US
dc.subjectOutcomesen_US
dc.titleThe importance of weight loss during definitive radiotherapy in patients with laryngeal carcinomaen_US
dc.typeArticleen_US

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