Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridChocholousova Havlikova, Lucie/0000-0001-6681-3723
dc.authoridSiatka, Tomas/0000-0002-2937-4466
dc.authoridCahlikova, Lucie/0000-0002-1555-8870
dc.authoridLocarek, Miroslav/0000-0002-0846-9589
dc.authoridAl Za'abi, Mohammed/0000-0002-2019-1022
dc.authoridOpletal, Lubomir/0000-0002-3874-3729
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidChocholousova Havlikova, Lucie/S-8904-2017
dc.authorwosidSiatka, Tomas/S-8723-2017
dc.authorwosidCahlikova, Lucie/T-5670-2017
dc.authorwosidLocarek, Miroslav/T-6307-2017
dc.authorwosidAl Za'abi, Mohammed/C-6591-2013
dc.authorwosidOpletal, Lubomir/H-5254-2012
dc.contributor.authorAli, Badreldin H.
dc.contributor.authorCahlikova, Lucie
dc.contributor.authorOpletal, Lubomir
dc.contributor.authorKaraca, Turan
dc.contributor.authorManoj, Priyadarsini
dc.contributor.authorRamkumar, Aishwarya
dc.contributor.authorAl Suleimani, Yousuf M.
dc.date.accessioned2024-06-12T10:50:40Z
dc.date.available2024-06-12T10:50:40Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectivesThe aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. MethodsRats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). Key findingsWhen either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. ConclusionsThe results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.en_US
dc.description.sponsorshipinternal University grant SQU [IG/MED/PHARM/1-2014]en_US
dc.description.sponsorshipThis research was partly supported from an internal University grant SQU (IG/MED/PHARM/1-2014), but received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.en_US
dc.identifier.doi10.1111/jphp.12748
dc.identifier.endpage1229en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue9en_US
dc.identifier.pmid28542915en_US
dc.identifier.scopus2-s2.0-85019913829en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1219en_US
dc.identifier.urihttps://doi.org/10.1111/jphp.12748
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18087
dc.identifier.volume69en_US
dc.identifier.wosWOS:000407083000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Pharmacy And Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenineen_US
dc.subjectAnthocyaninsen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectHibiscus Sabdariffaen_US
dc.subjectRatsen_US
dc.subject5/6 Nephrectomyen_US
dc.subjectInflammationen_US
dc.subjectInjuryen_US
dc.subjectL.en_US
dc.subjectAttenuateen_US
dc.subjectDiagnosisen_US
dc.subjectObesityen_US
dc.subjectGumen_US
dc.titleEffect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney diseaseen_US
dc.typeArticleen_US

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