Protective Effect of Flaxseed Oil on Renal Injury in Hyperlipidaemic Rats: The Effect of Flaxseed Oil on Hyperlipidaemia

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorKanter, Mehmet
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorAydogdu, Nurettin
dc.date.accessioned2024-06-12T11:03:35Z
dc.date.available2024-06-12T11:03:35Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study evaluated the possible effects of flaxseed oil on renal damage associated with hyperlipidaemic rats. Wistar albino male rats were divided into three groups. Group I was fed with a pellet chow. Group II was fed with a high cholesterol diet (HCD) consisting of 5% cholesterol and 0.35% cholic acid added to the pellet chow. Group III was fed with the same HCD, but were orally treated with a dose of 15 mg/kg body wt/day flaxseed oil. Flaxseed oil treatment started 1 week before and continued throughout the 22 weeks of the HCD. At the end of the experiment, renal tissue and blood samples were collected. The biochemical and histopathological findings confirmed renal damage in hypercholesterolaemia conditions. Flaxseed oil reduced the hypercholesterolaemia-induced increase in the serum levels of total cholesterol, LDL and urea. Oil red O stain revealed that lowered serum lipid was accompanied by a decreased deposition of neutral lipid. Flaxseed oil effectively reversed these abnormalities, verifying the protective effects of flaxseed oil in ameliorating renal injuries associated with hypercholesterolaemia. Copyright (C) 2010 John Wiley & Sons, Ltd.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [2008-72]en_US
dc.description.sponsorshipThis work was supported as Project 2008-72 by the Trakya University Research Center, Edirne, Turkey. The authors would like to thank Assistant Professor Fatma Nesrin Turan for statistical analysis.en_US
dc.identifier.doi10.1002/ptr.3334
dc.identifier.endpage802en_US
dc.identifier.issn0951-418X
dc.identifier.issn1099-1573
dc.identifier.issue6en_US
dc.identifier.pmid21077265en_US
dc.identifier.scopus2-s2.0-79957799355en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage796en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.3334
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21699
dc.identifier.volume25en_US
dc.identifier.wosWOS:000291060700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperlipidaemiaen_US
dc.subjectRenal Injuryen_US
dc.subjectFlaxseed Oilen_US
dc.subjectMorphologyen_US
dc.subjectBiochemistryen_US
dc.subjectInterstitial Fibrosisen_US
dc.subjectMechanismsen_US
dc.subjectTissuesen_US
dc.subjectAssayen_US
dc.titleProtective Effect of Flaxseed Oil on Renal Injury in Hyperlipidaemic Rats: The Effect of Flaxseed Oil on Hyperlipidaemiaen_US
dc.typeArticleen_US

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