Superoxide dismutase activity and the effect of N-methly-D-aspartate antagonists on lipid peroxidation in the early phase of cold injury

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dc.authoridKiris, Talat/0000-0002-2985-3758
dc.authorwosidKiris, Talat/AAP-4665-2020
dc.contributor.authorKiris, T
dc.contributor.authorGörgülü, A
dc.contributor.authorÜnal, F
dc.contributor.authorTürkoglu, Ü
dc.contributor.authorÇobanoglu, S
dc.contributor.authorEkuklu, G
dc.date.accessioned2024-06-12T10:58:04Z
dc.date.available2024-06-12T10:58:04Z
dc.date.issued1999
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFree radicals, lipid peroxidation and excitatory amino acids have been implicated in the secondary mechanisms of traumatic brain injury. We used the cold injury model in rats to assess the endogenous activity of the protective enzyme superoxide dismutase (SOD) and the lipid peroxidation level in the contused tissue at an early phase of injury. Furthermore, we treated the rats with two different N-methyl-D-aspartate receptor antagonists, namely MK-801 and CPP, and evaluated their effect on lipid peroxidation in the contused tissue. Rats were divided into four groups: sham, control, treatment 1 and treatment 2 groups (n = 16 for each group). Thirty and 60 min after craniectomy or injury, tissue samples were removed. SOD activity didn't change in this period. However, lipid peroxidation in terms of malondialdehyde (MDA) amount showed a significant increase at 60 min. Fifteen minutes after injury, MK-801 (1 mg/kg), CPP (10 mg/kg) or saline (1 ml) were applied intraperitoneally in treatment 1, treatment 2 and the control groups, Treatment with MK-801 attenuated MDA levels, whereas treatment with CPP did not. The protective effect of MK-801 achieved statistical significance. These results demonstrate that SOD activity does not change in the Parry period of cold injury. Moreover, these results show that lipid peroxidation increases after 60 min of cold injury, and treatment with MK-801 15 min after injury can prevent this elevation.en_US
dc.identifier.doi10.1007/s004330050116
dc.identifier.endpage347en_US
dc.identifier.issn0300-9130
dc.identifier.issue6en_US
dc.identifier.pmid10369089en_US
dc.identifier.scopus2-s2.0-0032932199en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1007/s004330050116
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19924
dc.identifier.volume198en_US
dc.identifier.wosWOS:000080325500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofResearch In Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold Injuryen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMK-801en_US
dc.subjectNMDA Antagonisten_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectSpinal-Cord Injuryen_US
dc.subjectVasogenic Brain Edemaen_US
dc.subjectOxygen Free-Radicalsen_US
dc.subjectAmino-Acid Releaseen_US
dc.subjectNeurological Disordersen_US
dc.subjectIschemiaen_US
dc.subjectExcitotoxicityen_US
dc.subjectInvolvementen_US
dc.subjectGlutamateen_US
dc.subjectReceptorsen_US
dc.titleSuperoxide dismutase activity and the effect of N-methly-D-aspartate antagonists on lipid peroxidation in the early phase of cold injuryen_US
dc.typeArticleen_US

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