Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure

Basit Öğe Kaydı
dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:16:29Z
dc.date.available2024-06-12T11:16:29Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was designed to evaluate the possible protective effects of thymoquinone (TQ) on the neuronal injury in the frontal cortex after chronic toluene exposure in rats. The rats were randomly allotted into one of three experimental groups: A (control), B (toluene treated) and C (toluene treated with TQ); each group contain 10 animals. Control group received 1ml normal saline solution and toluene treatment was performed by inhalation of 3,000 ppm toluene, in a 8 h/day and 6 day/week order for 12 weeks. The rats in TQ treated group was given TQ (50 mg/kg body weight) once a day orally for 12 weeks starting just after toluene exposure. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of neurodegeneration in the frontal cortex after chronic toluene exposure in rats by TQ treatment have been reported. In this study, the morphology of neurons in the TQ treatment group was well protected. Chronic toluene exposure caused severe degenerative changes, shrunken cytoplasma, severely dilated cisternae of endoplasmic reticulum, markedly swollen mitochondria with degenerated cristae and nuclear membrane breakdown with chromatin disorganization in neurons of the frontal cortex. We conclude that TQ therapy causes morphologic improvement on neurodegeneration in frontal cortex after chronic toluene exposure in rats. We believe that further preclinical research into the utility of TQ may indicate its usefulness as a potential treatment on neurodegeneration after chronic toluene exposure in rats.en_US
dc.identifier.doi10.1007/s10735-010-9305-3
dc.identifier.endpage46en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1en_US
dc.identifier.pmid21120684en_US
dc.identifier.scopus2-s2.0-79954448000en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-010-9305-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24334
dc.identifier.volume42en_US
dc.identifier.wosWOS:000288806500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTolueneen_US
dc.subjectThymoquinoneen_US
dc.subjectMorphologyen_US
dc.subjectFrontal Cortexen_US
dc.subjectRatsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectNigella-Sativaen_US
dc.subjectDevelopmental Toxicityen_US
dc.subjectRatsen_US
dc.subjectBrainen_US
dc.subject1,1,1-Trichloroethaneen_US
dc.subjectNeurodegenerationen_US
dc.subjectHippocampusen_US
dc.subjectInhalationen_US
dc.subjectEthanolen_US
dc.titleProtective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposureen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu