Association of paraoxonase (PON1) polymorphisms and activity with colorectal cancer predisposition

Basit Öğe Kaydı
dc.authoridergen, arzu/0000-0001-5736-8453
dc.authoridYaylim, Ilhan/0000-0003-2615-0202
dc.authoridTekant, Yaman/0000-0001-8926-7948
dc.authoridIsbir, Turgay/0000-0002-7350-6032
dc.authorwosidergen, arzu/P-6554-2019
dc.authorwosidDemirel, Tugrul/JAC-3486-2023
dc.contributor.authorDemirel, Tugrul
dc.contributor.authorYaylim, Ilhan
dc.contributor.authorErgen, Hayriye Arzu
dc.contributor.authorGunay, Mustafa Kayihan
dc.contributor.authorTekant, Yaman
dc.contributor.authorIsbir, Turgay
dc.date.accessioned2024-06-12T11:12:04Z
dc.date.available2024-06-12T11:12:04Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractParaoxonase 1 (PON1) is a well recognised member of human endogeneous free radical scavenging systems and its polymorphism and enzyme activity are attributed to various different cancer formations. We aimed to study the Paraoxonase 1 (PON1) polymorphism and enzyme activity in colorectal cancer patients. Peripheral blood samples for DNA extraction were collected from 54 colorectal cancer patients and 85 healthy individuals. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were used for determination of the PON1192 polymorphism. The frequency of AA genotype was greater than BB and AB genotypes in all groups (n:65 with 46.8%; n:15 with 10.8% and n:59 with 42.4%, respectively). In both tumor groups, PON activities were significantly lower than the control group (p < 0.05). The AA genotype was significantly more frequent than the AB and BB genotypes in colorectal cancer patients. Although the rectum cancer patients' number is low in our study, we hypothesise that decreased enzyme activity of PON 1 related to 192 gene polymorphisms might have a role in the formation of an oxidative microenvironment for cancerous DNA damage which may tend to increase distally in the colon. Further studies considering the location and the stage of the colorectal tumors with more patients may put a broadly wider view on this polymorphism and enzyme activity with respect to cancer formation.en_US
dc.identifier.doi10.1080/13102818.2020.1867006
dc.identifier.endpage238en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85098632198en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2020.1867006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23029
dc.identifier.volume35en_US
dc.identifier.wosWOS:000603868000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParaoxonase 1en_US
dc.subjectAntioxidanten_US
dc.subjectPolymorphismen_US
dc.subjectColorectal Canceren_US
dc.subjectPredispositionen_US
dc.subjectGenetic-Polymorphismen_US
dc.subjectOxidative Stressen_US
dc.subjectNatural-Historyen_US
dc.subjectProstate-Canceren_US
dc.subjectMolecular-Basisen_US
dc.subjectArylesteraseen_US
dc.subjectRisken_US
dc.subjectDnaen_US
dc.subjectPathologyen_US
dc.subjectDamageen_US
dc.titleAssociation of paraoxonase (PON1) polymorphisms and activity with colorectal cancer predispositionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu