Role of Amifostine on Acute and Late Radiation Nephrotoxicity: A Histopathological Study

Basit Öğe Kaydı
dc.contributor.authorKanter, Mehmet
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorUzal, Cem
dc.date.accessioned2024-06-12T10:51:24Z
dc.date.available2024-06-12T10:51:24Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The present study was performed to determine the effect of amifostine in the prevention of radiation-induced acute and late period morphologic damages in rat kidney via light and electron microscopic examinations. Materials and Methods: Control rats (n=6) received saline solution 30 min before sham irradiation; the radiotherapy alone group (n=12) received saline solution 30 min before irradiation (a single dose of 15 Gy, applied unilaterally to the kidney) and a final radiotherapy +amifostine group (n=12) received 200 mg/kg amifostine 30 min prior to irradiation. Results: Microscopic examinations of irradiated kidneys revealed presence of glomerular tuft capsular adhesion, fusion of the foot processes and ballon-like cellular degeneration and loss of luminal brush border in tubules as early as eight weeks after irradiation. By 24 weeks post-irradiation, these changes were advanced and associated with focal mesangiolysis, segmental sclerosis and focal tubular atrophy. In addition, local irradiation caused interstitial fibrotic lesions in the kidney. Pretreatment of amifostine markedly prevented these glomerular and tubular changes, and interstitial fibrotic lesions. Conclusion: This study suggests that amifostine pretreatment may contribute to prevention of radiation-induced acute and late nephrotoxicity.en_US
dc.identifier.endpage85en_US
dc.identifier.issn0258-851X
dc.identifier.issue1en_US
dc.identifier.pmid21282738en_US
dc.identifier.scopus2-s2.0-79952030309en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18356
dc.identifier.volume25en_US
dc.identifier.wosWOS:000287296800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofIn Vivoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectNephrotoxicityen_US
dc.subjectInterstitial Fibrosisen_US
dc.subjectRenal Fibrosisen_US
dc.subjectMouse Kidneyen_US
dc.subjectCells Altersen_US
dc.subjectNephropathyen_US
dc.subjectWr-2721en_US
dc.subjectRaten_US
dc.subjectIrradiationen_US
dc.subjectProtectionen_US
dc.subjectDamageen_US
dc.subjectRadioprotectionen_US
dc.titleRole of Amifostine on Acute and Late Radiation Nephrotoxicity: A Histopathological Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu