A comparison of oral midazolam, oral tramadol, and intranasal sufentanil premedication in pediatric patients

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dc.authorscopusid16309028400
dc.authorscopusid6506025620
dc.authorscopusid7003369853
dc.authorscopusid7004533485
dc.contributor.authorBayrak F.
dc.contributor.authorGunday I.
dc.contributor.authorMemis D.
dc.contributor.authorTuran A.
dc.date.accessioned2024-06-12T10:26:24Z
dc.date.available2024-06-12T10:26:24Z
dc.date.issued2007
dc.description.abstractBackground: This study was designed to evaluate the efficacy and safety of oral midazolam, tramadol drops, and intranasal sufentanil for premedication of pediatric patients. Methods: Sixty children, three to 10 years of age, who were designated as American Society of Anesthesiologists physical status I and who were undergoing adenotonsillectomy as inpatients were randomized to receive a dosage of 0.5 mg/kg (total of 4 mL) midazolam in cherry juice (n = 20, Group M), 3 mg/kg tramadol drops (n = 20, Group T), or 2 ?g/kg intranasal sufentanil (n = 20, Group S). Clinical responses (sedation, anxiolysis, cooperation) and adverse effects (respiratory, hemodynamic, etc.) were recorded. Safety was assessed by continuous oxygen saturation monitoring and observation. Vital signs (blood pressure, pulse, oxygen saturation, respiratory rate) were recorded before drug administration (baseline) and then every 10 minutes until the induction of anesthesia. Results: Mean blood pressure decreased significantly after five minutes of intranasal sufentanil administration relative to Groups M (p < 0.01) and T (p < 0.05), whereas heart rate remained unchanged. Oxygen saturation and respiratory rate decreased significantly after 20 and 30 minutes of intranasal sufentanil administration relative to Groups M and T (p < 0.05). Anxiety scores showed rates of 45 percent in Group M, 5 percent in Group T, and 40 percent in Group S. Anxiety scores in Groups M and S were better than those of Group T (p < 0.01). Cooperation scores for face-mask acceptance showed rates of 85 percent in Group M, 45 percent in Group T, and 85 percent in Group S (p < 0.01). Conclusion: Intranasal sufentanil and oral midazolam are more appropriate premedication options than tramadol drops in children.en_US
dc.identifier.doi10.5055/jom.2007.0043
dc.identifier.endpage78en_US
dc.identifier.issn1551-7489
dc.identifier.issue2en_US
dc.identifier.pmid17520986en_US
dc.identifier.scopus2-s2.0-34248578779en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.5055/jom.2007.0043
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16835
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWeston Medical Publishingen_US
dc.relation.ispartofJournal of Opioid Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildren; Intranasal Sufentanil; Oral Midazolam; Oral Tramadolen_US
dc.subjectAtropine; Midazolam; Neostigmine; Sevoflurane; Sufentanil; Tramadol; Vecuronium; Adenotonsillectomy; Anesthesia; Anxiety; Article; Breathing Rate; Clinical Trial; Controlled Clinical Trial; Controlled Study; Cooperation; Drug Efficacy; Drug Response; Drug Safety; Face Mask; Female; Heart Rate; Human; Major Clinical Study; Male; Mean Arterial Pressure; Nausea; Oxygen Saturation; Pediatric Anesthesia; Premedication; Preschool Child; Randomized Controlled Trial; Sedation; Side Effect; Tranquilizing Activity; Vital Signen_US
dc.titleA comparison of oral midazolam, oral tramadol, and intranasal sufentanil premedication in pediatric patientsen_US
dc.typeArticleen_US

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