The effect of the prebiotic solutions in treatment of severe sepsis

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dc.contributor.authorMemis, Dilek
dc.contributor.authorYelken, Birguel
dc.contributor.authorSahin, Sevtap Hekimoglu
dc.contributor.authorVatan, Ilke
dc.contributor.authorYardim, Tarik
dc.date.accessioned2024-06-12T10:58:52Z
dc.date.available2024-06-12T10:58:52Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: In this double blind, prospective and randomized study, the effects of the enteral administration of a prebiotic preparation containing oligofructose and inulin on upper gastrointestinal colonization and systemic inflammation in intensive care patients with severe sepsis were investigated. Patients and Methods: A total of 50 patients admitted to an intensive care unit were randomized to receive either prebiotic (group 1, n=25) or placebo preparations (group 2, n=25). The prebiotic preparation consisted of prebiotic fiber inulin-oligofructose (0.8 g/100 mL, A, D3, E vitamins). Gut barrier function was assessed by culture of nasogastric aspirate on the first and eighth days. All septic complications, acute physiology and chronic health evaluation II (APACHE II) scores, ventilation days, gastrointestinal culture results, biochemical parameters, C-reactive protein (CRP) and mortality ratios were recorded. Results: There were no differences between the groups in terms of age, sex, APACHE II scores, CRP, ventilation days. There were no significant differences between the groups in terms of gastrointestinal culture, septic complications or mortality. Conclusion: The administration of prebiotic solution in intensive care patients with severe sepsis had no effect on gastrointestinal permeability, gastric colonisation, the systemic inflammatory response and morbidity.en_US
dc.identifier.endpage199en_US
dc.identifier.issn1301-3149
dc.identifier.issue3en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20218
dc.identifier.volume24en_US
dc.identifier.wosWOS:000257677100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCritical Illness/Mortalityen_US
dc.subjectPrebioticsen_US
dc.subjectSepsisen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectGut Barrier Functionen_US
dc.subjectGastrointestinal-Tracten_US
dc.subjectProbioticsen_US
dc.subjectIndicatoren_US
dc.titleThe effect of the prebiotic solutions in treatment of severe sepsisen_US
dc.typeArticleen_US

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