Comparison of the efficacy of the immediate-release and osmotic push-pull system formulations of nifedipine for tocolysis

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorIran, Cihan
dc.contributor.authorSayin, Cenk
dc.contributor.authorDolgun, Nihal
dc.contributor.authorUzun, Isil
dc.contributor.authorErzincan, Selen G.
dc.contributor.authorSutcu, Havva
dc.contributor.authorVarol, Fusun
dc.date.accessioned2024-06-12T11:09:04Z
dc.date.available2024-06-12T11:09:04Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim To compare the immediate-release (IR) and osmotic push-pull system formulations of nifedipine used for tocolysis in prolonging pregnancy, neonatal outcomes and maternal-fetal adverse effects. Methods We evaluated 140 pregnant women who received the IR (n = 72) and osmotic push-pull system (n = 68) formulations of nifedipine for tocolysis due to threatened preterm labor between 24(0/7) and 33(6/7) weeks of gestation. Groups were compared in terms of efficacy of tocolysis in prolonging pregnancy for more than 48 h, 7 days and up to 37 weeks of gestation, total number of days gained for prolonging pregnancy, delivery weeks, maternal-fetal adverse effects and neonatal outcomes including ventilation support, need for intubation or surfactant, intraventricular hemorrhage, respiratory distress syndrome, necrotizing enterocolitis, admission to neonatal intensive care unit, neonatal death, Apgar scores at the 1st and 5th minutes. Results There was no significant difference between the two groups in prolonging pregnancy for more than 48 h or 7 days, total number of days gained after tocolysis initiation, delivery weeks, the number of births at 34(0/7)-36(6/7) weeks or after 37 weeks of gestation (P > 0.05). Maternal-fetal adverse effects and neonatal outcomes were similar in both groups (P > 0.05). Conclusion The efficacy of IR and osmotic push-pull system formulations of nifedipine have similar effects in terms of tocolysis and neonatal outcomes, adverse effects. Osmotic push-pull system formulation of nifedipine may be an alternative medication in tocolytic therapy due to its ease of use and the absence of loading dose necessity.en_US
dc.identifier.doi10.1111/jog.14126
dc.identifier.endpage2357en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue12en_US
dc.identifier.pmid31608543en_US
dc.identifier.scopus2-s2.0-85074048553en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2351en_US
dc.identifier.urihttps://doi.org/10.1111/jog.14126
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22676
dc.identifier.volume45en_US
dc.identifier.wosWOS:000489866700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeonateen_US
dc.subjectNifedipineen_US
dc.subjectPreterm Laboren_US
dc.subjectTocolysisen_US
dc.subjectUterine Contractionen_US
dc.subjectPreterm Laboren_US
dc.subjectPharmacokineticsen_US
dc.subjectMetaanalysisen_US
dc.subjectManagementen_US
dc.subjectBirthen_US
dc.titleComparison of the efficacy of the immediate-release and osmotic push-pull system formulations of nifedipine for tocolysisen_US
dc.typeArticleen_US

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