The Effect of N-acetylcysteine on Brain Tissue of Rats Fed with High-Cholesterol Diet

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dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorAltaner, Semsi
dc.contributor.authorBayir, Serpil
dc.contributor.authorCakir, Erol
dc.date.accessioned2024-06-12T11:08:56Z
dc.date.available2024-06-12T11:08:56Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The effect of N-acetylcysteine in rats fed a high-cholesterol diet on oxidative stress in the plasma and brain tissue of rats was investigated. Methods: The animals were maintained on a basal diet (control, n=10) or a high-cholesterol diet (1 % w/w) for eight weeks. The rats fed high-cholesterol diet were separated to three group; high-cholesterol diet (n=10), low N-acetylcysteine (n=10) and high N-acetylcysteine groups (n=9). Low and high N-acetylcysteine groups received N-acetylcysteine at a dose of 50 and 100 mg/kg/day respectively via intraperitoneally for eight weeks. Malondialdehyde, glutathione, nitric oxide, cholesterol and triglyceride levels were analyzed in the samples. The results were analyzed by Kruskal-Wallis variance analysis and then a Mann-Whitney U test. Results: When N-acetylcysteine was administered at a low dose, lipid peroxidation products in the brain significantly decreased compared with the high-cholesterol group, while glutathione content enhanced. On the other hand, when N-acetylcysteine was administered at a high dose, lipid peroxidation products in the brain and plasma significantly increased compared with the control group. Conclusions: These results suggest that N-acetylcysteine has a dual effect. If the N-acetylcysteine dose was carefully selected, N-acetylcysteine may have a neuroprotective effect against oxidative stress and hypercholesterolemia.en_US
dc.identifier.endpage63en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.startpage58en_US
dc.identifier.trdizinid83758en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/83758
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22617
dc.identifier.volume33en_US
dc.identifier.wosWOS:000260581100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectHigh-Cholesterol Dieten_US
dc.subjectNitric Oxideen_US
dc.subjectLipid Peroxidationen_US
dc.subjectGlutathioneen_US
dc.subjectPlasma Lipidsen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectOxidative Stressen_US
dc.subjectFree-Radicalsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectInduced Toxicityen_US
dc.subjectAcetyl-Cysteineen_US
dc.subjectIn-Vivoen_US
dc.subjectAntioxidanten_US
dc.subjectGlutathioneen_US
dc.subjectReductionen_US
dc.titleThe Effect of N-acetylcysteine on Brain Tissue of Rats Fed with High-Cholesterol Dieten_US
dc.typeArticleen_US

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