Effects of kefir on ischemia-reperfusion injury

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dc.authoridŞehitoğlu, M Hilal/0000-0003-4436-9160
dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidEkin, Atalay/JTS-8795-2023
dc.authorwosidEkin, Atalay/GNP-8013-2022
dc.authorwosidŞehitoğlu, M Hilal/V-3841-2019
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidYener, Ali Ümit/AAT-4990-2021
dc.contributor.authorYener, A. U.
dc.contributor.authorSehitoglu, M. H.
dc.contributor.authorOzkan, M. T. A.
dc.contributor.authorBekler, A.
dc.contributor.authorEkin, A.
dc.contributor.authorCokkalender, O.
dc.contributor.authorDeniz, M.
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to investigate the effect of kefir on Ischemia-Reperfusion (I/R) injury on rats. MATERIALS AND METHODS: 24 male Sprague-Dawley rats between 250-350 g were selected. Rats were divided into three groups, and there were eight rats in each group. Rats were fed for 60 days. All of the rats were fed with the same diet for the first 30 days. In the second thirty days, kefir [10 cc/kg/day body weight (2 x 10(9) cfu/kg/day)] was added to the diet of the study group by gavage method. In all groups, lung and kidney tissues were removed after the procedure and rats were sacrificed. The biochemical and histopathological changes were observed in the lung and kidney within the samples. Serum urea, creatinine and tumor necrosis factor (TNF-alpha) were determined. RESULTS: Kefir + I/R groups was compared with I/R groups, a significant decrease (p < 0.05) was seen in Lipid peroxidation (MDA) levels of lung and renal tissues. Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activities of lung and kidney tissues decreased in I/R groups (p < 0.05). The enzyme activities in Kefir + I/R groups of renal tissues were significantly (p < 0.05) higher than I/R, not significantly different in lung tissues (p < 0.05). Kefir reduced the levels of serum urea, creatinine and TNF-alpha significantly. CONCLUSIONS: This would be useful in this model against ischemia/reperfusion, and shows the protective effect of kefir in tissue and serum functions.en_US
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission [TSA-2014-135]en_US
dc.description.sponsorshipThis study supported by Canakkale Onsekiz Mart University Scientific Research Projects Commission (no: TSA-2014-135).en_US
dc.identifier.endpage896en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid25807443en_US
dc.identifier.scopus2-s2.0-84942257383en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage887en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22006
dc.identifier.volume19en_US
dc.identifier.wosWOS:000352642700026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKefiren_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectLungen_US
dc.subjectKidneyen_US
dc.subjectLactobacillusen_US
dc.subjectMiceen_US
dc.subjectBifidobacteriumen_US
dc.subjectGlutathioneen_US
dc.subjectPathwaysen_US
dc.subjectBacteriaen_US
dc.subjectGrainsen_US
dc.subjectGshen_US
dc.titleEffects of kefir on ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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