Evaluation of Genotoxic and Cytotoxic Effects of Natamycin in Mice Bone Marrow Cells

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dc.authoridGOC RASGELE, Pinar/0000-0002-7558-3138
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorKaymak, Fisun
dc.date.accessioned2024-06-12T11:09:00Z
dc.date.available2024-06-12T11:09:00Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNatamycin, food preservative, is widely used in food industry against yeast and fungi. The potential genotoxicity of a commercial formulation of natamycin (Delvocid, containing 50% natamycin as the active ingredient) in mice bone marrow cells Was investigated in vivo by chromosome aberrations (CA) and micronucleus assays (MA). Animals were intraperitoneally treated with 200, 400 and 800 mg/kg of natamycin for 6, 12 and 24 h in CA assay, for 24, 48 and 72 hours in MN assay. In the present study, natamycin did not increase chromosome aberrations. It significantly induced frequency of micronucleus at all concentrations for both 24 and 48 h in female mice, at the two highest (400 and 800 mg/kg) concentrations for both 24 and 48 h in male mice when compared with negative control. Mice bone marrow erythrocytes exposed to all concentrations of natamycin showed significant. decreases in mitotic index for all treatment periods. In addition, natamycin reduced polychromatic erytrocyte/normochromatic erytrocyte ratio at all concentrations for 48h and at the highest (800 mg/kg) concentration for 24 and 72h in female mice; at all concentrations for 24 and 48h in male mice. The results of the present study show that a commercial formulation of natamycin was aneugenic and cytotoxic to mice bone marrow in vivo. For this reason it is necessary to be careful when using these chemicals in food as preservatives.en_US
dc.description.sponsorshipTrakya University Scientific Research Fund [TUBAP-751]en_US
dc.description.sponsorshipThis study was supported by Trakya University Scientific Research Fund with the project number TUBAP-751 and it is part of doctoral thesis titled Toxic effects of Delvocid on Mus musculus.en_US
dc.identifier.endpage1112en_US
dc.identifier.issn0030-9923
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84884129715en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1103en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22653
dc.identifier.volume45en_US
dc.identifier.wosWOS:000328301100030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherZoological Soc Pakistanen_US
dc.relation.ispartofPakistan Journal Of Zoologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNatamycinen_US
dc.subjectFood Additiveen_US
dc.subjectChromosome Aberrationen_US
dc.subjectMicronucleusen_US
dc.subjectMice Bone Marrowen_US
dc.subjectSister-Chromatid Exchangesen_US
dc.subjectCultured Human-Lymphocytesen_US
dc.subjectChromosome-Aberrationsen_US
dc.subjectMicronucleus Testen_US
dc.subjectSodium Metabisulfiteen_US
dc.subjectFood Preservativesen_US
dc.subjectCytogenetic Damageen_US
dc.subjectInvivoen_US
dc.subjectAssayen_US
dc.titleEvaluation of Genotoxic and Cytotoxic Effects of Natamycin in Mice Bone Marrow Cellsen_US
dc.typeArticleen_US

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