Protective effect of L-carnitine on testicular ischaemia-reperfusion injury in rats

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dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorInan, Mustafa
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorYalcin, Omer
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorTuran, Fatma Nesrin
dc.contributor.authorUz, Yesim Hulya
dc.date.accessioned2024-06-12T11:16:10Z
dc.date.available2024-06-12T11:16:10Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTesticular torsion is a urological emergency referred to as acute scrotum', because inappropriate treatment can lead to male subfertility and infertility. A possible cause of testicular damage is the ischaemia-reperfusion (I/R) injury attributed to oxygen free radicals. L-carnitine, a vitamin-like antioxidant, plays a pivotal role in the maturation of spermatozoa within the reproductive tract. The aim of the present paper was to determine the protective effect Of L-carnitine on testicular I/R-induced injury. Thirty-two male rats were divided into 4 groups (n = 8). Testicular torsion was created by rotating the right testis 720 degrees in a clockwise direction. Group 1: sham-operated control; group 2: ischaemia; group 3: I/R; group 4: ischaemia-L-camitine treatment-reperfusion group. L-carnitine (500mg kg(-1), intraperitoneally) was administered before 30 min of detorsion in Group 4. After torsion (5 h) and detorsion (5 h), bilateral orchidectomy was performed. The malondialdehyde (MDA) level was evaluated in testes. Histopathologically, Johnsen's spermatogenesis criteria and mean seminiferous tubule diameter (MSTD) measurements were used. Testicular MDA levels were higher in the torsion group compared to the sham-control group (p < 0.05). Detorsion (reperfusion) caused a further increase in MDA levels (p < 0.05). Pretreatment with L-camitine prevented a further increase in MDA levels (p < 0.05). Histologically, torsion caused some separation among germinal cells in the seminiferous tubules, which became much more prominent in the I/R group but was attenuated with L-carnitine pretreatment. In conclusion, L-carnitine pretreatment may have a protective effect in experimental testicular torsiondetorsion model in rats by its well-known antioxidant potential. Copyright (C) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1355
dc.identifier.endpage618en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6en_US
dc.identifier.pmid16883624en_US
dc.identifier.scopus2-s2.0-33947696375en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage611en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1355
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24204
dc.identifier.volume25en_US
dc.identifier.wosWOS:000251002300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry And Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular Torsionen_US
dc.subjectIschaemia-Reperfusionen_US
dc.subjectMale Infertilityen_US
dc.subjectL-Carnitineen_US
dc.subjectAntioxidanten_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzyme-Activitiesen_US
dc.subjectOxidative Stressen_US
dc.subjectSeminal Plasmaen_US
dc.subjectVitamin-Een_US
dc.subjectTorsionen_US
dc.subjectSemenen_US
dc.subjectSupplementationen_US
dc.subjectAllopurinolen_US
dc.subjectInfertilityen_US
dc.subjectMelatoninen_US
dc.titleProtective effect of L-carnitine on testicular ischaemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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