Radiotherapy as the primary and palliative treatment for patients aged 75 and over with locally advanced and metastatic non-small cell lung cancer: Analysis of 45 cases with a review of the literature
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the prognostic factors and treatment results of Turkish patients aged 75 and over with locally advanced and metastatic non-small cell lung cancer (NSCLC). Patients and Methods: Forty-five patients ? 75 years were evaluated. The median age was 78 (75-93). Thirty-four patients (75%) had stage IIIB and 11 patients had stage IV disease (25%). Fourteen patients (41%) with stage IIIB disease were treated with curative radiotherapy (RT), 18 patients (52%) with palliative RT and 2 patients (5%) were treated with only chemotherapy (CT). Results: The one-year survival rate was 37%. The overall median survival was 12.7 months in stage IIIB and 7.67 months in stage IV. In univariate analysis, advanced stage (p=0.0006), performance status (p=0.056), absence of radiotherapy (p=0.0008) and weight loss (p=0.0053) adversely affected survival. In multivariate analysis only stage IV was found to be a statistically significant independent poor prognostic factor (p=0.0025 HR=0.2760 (0.12-0.60) 95% confidence interval). Conclusion: In Turkish patients, with NSCLC, aged 75 or over, stage IV disease was associated with poor prognosis. The higher radiotherapy doses did not improve survival in patients with stage IIIB disease and the prognosis with only radiotherapy is similar to the results of chemoradiation in the literature in this age group.
Açıklama
Anahtar Kelimeler
Chemotherapy; Elderly; Lung Cancer; Prognostic Factors; Radiotherapy, Cisplatin; Advanced Cancer; Aged; Article; Cancer Localization; Cancer Staging; Cancer Survival; Clinical Article; Disease Association; Disease Course; Dysphagia; Febrile Neutropenia; Female; Human; Lung Non Small Cell Cancer; Male; Metastasis; Neutropenia; Pneumonia; Prognosis; Survival Rate
Kaynak
Marmara Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
21
Sayı
1
