Effects of Intratympanic Steroid on Cisplatin Ototoxicity: An Electrophysiological and Ultrastructural Study

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dc.authorwosidBULUT, Erdoğan/C-4135-2015
dc.contributor.authorTas, Abdullah
dc.contributor.authorBulut, Erdogan
dc.contributor.authorTas, Memduha
dc.contributor.authorYagiz, Recep
dc.contributor.authorTuran, Pinar
dc.contributor.authorHuseyinoglu, Aydin
dc.contributor.authorKarasalihoglu, Ahmet R.
dc.date.accessioned2024-06-12T10:56:34Z
dc.date.available2024-06-12T10:56:34Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOtotoxicity refers to the inner ear dysfunction caused by a drug or a chemical agent which manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics, anti-inflammatory drugs, antineoplastic agents, antimalarial drugs and some other agents are known to cause ototoxicity. Cisplatin is an antineoplastic agent for which the ototoxicity incidence may vary based on the treatment protocol. In the present study, we aimed to perform an electrophysiological and ultrastructural evaluation regarding the protective effectiveness of intratympanic steroids on cisplatin ototoxicity. Electrophysiological assessment included tympanometry and auditory brainstem response (ABR), and 16 guinea pigs (32 ears) with normal hearing were randomly assigned to 4 groups as follows: control, cisplatin, cisplatin/steroid and cisplatin/physiological saline. Following the electrophysiological measurements, temporal bones were dissected for ultrastructural examinations. In the cisplatin group, a statistically significant (p<0.05) threshold difference was noted for the ABR test versus the other groups while this threshold difference was lower in the cisplatin/steroid group compared to the other groups. Ultrastructural evaluations revealed abnormal outer hair cell stereocilia morphology and severe degenerative changes in the cisplatin and cisplatin/physiological saline groups. Mild degenerative alterations were seen in the outer hair cell stereocilia morphology in the guinea pig cochlea administered with intratympanic steroid. We believe intratympanic steroid administration showed protective effectiveness on the cisplatin-induced ototoxic damage in our study.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey-Marmara Research Centre (TUBITAK-MAM), Gebze, Kocaelien_US
dc.description.sponsorshipWe are grateful to The Scientific and Technological Research Council of Turkey-Marmara Research Centre (TUBITAK-MAM), Gebze, Kocaeli, for their support with the SEM examination.en_US
dc.identifier.doi10.4999/uhod.181742
dc.identifier.endpage111en_US
dc.identifier.issn1306-133X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85048564456en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage104en_US
dc.identifier.trdizinid287810en_US
dc.identifier.urihttps://doi.org/10.4999/uhod.181742
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/287810
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19841
dc.identifier.volume28en_US
dc.identifier.wosWOS:000435383300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectElectron Microscopyen_US
dc.subjectAuditory Evoked Brainstem Responsesen_US
dc.subjectMethylprednisoloneen_US
dc.subjectGuinea-Pigen_US
dc.subjectDexamethasoneen_US
dc.subjectMethylprednisoloneen_US
dc.subjectPreventionen_US
dc.subjectPerilymphen_US
dc.subjectInjectionen_US
dc.subjectToxicityen_US
dc.subjectProtectsen_US
dc.subjectHearingen_US
dc.subjectCanceren_US
dc.titleEffects of Intratympanic Steroid on Cisplatin Ototoxicity: An Electrophysiological and Ultrastructural Studyen_US
dc.typeArticleen_US

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