The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury

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dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorKocak, Zafer
dc.contributor.authorShankar, Lalitha
dc.contributor.authorSullivan, Daniel C.
dc.contributor.authorMarks, Lawrence B.
dc.coverage.doi10.1007/978-3-540-49070-8
dc.date.accessioned2024-06-12T11:17:44Z
dc.date.available2024-06-12T11:17:44Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe recognition and assessment of normal tissue injury is an important aspect of radiation oncology practice and a critical endpoint in clinical studies. One of the major challenges in the study of radiation (RT)-induced normal tissue injury is determining the appropriate endpoint. Patients' symptoms have obvious clinical relevance; however, the scoring of symptoms is relatively subjective. Conversely, radiologic endpoints are potentially quantifiable and are available for objective I study. Furthermore, radiologic evidence of subclinical normal tissue injury is far more common than are clinical symptoms, providing a larger number of patients with identifiable injury for study. We review herein radiologically-detected normal tissue injury as it relates to the lung, heart, brain, and salivary glands. The concepts described are likely to be similar for other organs. We conclude that: (1) radiologically-defined normal tissue injury in human patients may be related to long-term clinically meaningful injury, but further study is needed to better quantify this association; (2) radiologically-defined normal tissue injury in human patients is manifest soon after (or even during) RT and hence is a potential tool to rapidly study potential mitigators of this injury in humans; and (3) additional work is needed to develop standards to quantitatively score radiologic injury. Thus, advances in anatomic and functional imaging afford unique opportunities to facilitate the study of radiation-associated normal tissue injury.en_US
dc.identifier.endpage45en_US
dc.identifier.isbn978-3-540-49069-2
dc.identifier.issn0942-5373
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24822
dc.identifier.wosWOS:000267389600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Berlinen_US
dc.relation.ispartofCured I - Lent: Late Effects Of Cancer Treatment On Normal Tissuesen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast-Cancer Patientsen_US
dc.subjectDose-Volume Histogramen_US
dc.subjectEmission Computed-Tomographyen_US
dc.subjectLocal Pulmonary Injuryen_US
dc.subjectCell Lung-Canceren_US
dc.subjectAdjuvant Radiotherapyen_US
dc.subjectFollow-Upen_US
dc.subjectMalignant-Lymphomaen_US
dc.subjectGlucose-Metabolismen_US
dc.subjectMyocardial Damageen_US
dc.titleThe Role of Imaging in the Study of Radiation-Induced Normal Tissue Injuryen_US
dc.typeBook Chapteren_US

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