The analgesic efficacy of intraperiloneally administered ondansetron in laparoscopic cholecystectomies
Küçük Resim Yok
Tarih
2003
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A standart premedication, anaesthetic induction and maintenance was performed to 82 patients undergoing laparoscopic cholecystectomy to evaluate the analgesic efficacy of ondansetron when administered via intraperitoneal route. Patients were assigned to four groups to receive intraperitoneally 20 mL of: % 0.9 NaCl (Group I, n=20); % 0.5 bupivacaine (Group II, n=20); 8 mg ondansetron (Group III, n=20) or % 0.5 bupivacaine+8 mg ondansetron (Group IV, n=22) in a double blind manner. Pain, duration of analgesia, rescue analgesic medication (75 mg diclofenac, IM and, heart rate, systolic and diastolic arterial pressure were assessed at 0 and 30th min, 1, 2, 4, 8, 12 and 24th hours postoperatively. In Group II and IV, pain scores (Numeric Rating Scale) were lower during first 4 hours when compared with Group I and III (p<0.001); pain scores were lower in group IV when compared with Group I (p<0.05) and III (p<0.001) at 8th hour. At 12th hour, pain scores in group IV were lower than all other groups (p<0.01 for groups I and III; p<0.05 for group II). Duration of analgesia was longer in group IV when compared with other groups and, in Group II when compared with Groups I and III (p<0.01, p<0.001). Analgesic consumption was lower in the same groups (p<0.01, p<0.001). Heart rate was higher in Group I at 0, 30th min, 1 and 2nd hours and, systolic arterial pressure was higher in Group I when compared with other groups at Oth min (p<0.05, p<0.01, p<0.001; P<0.05). As a result, it is concluded that ondonsetron alone has not analgesic efficacy, although it increases the analgesic efficacy of bupivacaine when administered intraperitoneally.
Açıklama
Anahtar Kelimeler
Bupivocaine; Intraperitoneal Administration; Laparoscopic Cholecystectomy; Ondansetron; Postoperative Analgesia, Atracurium; Atropine; Bupivacaine; Diclofenac; Midazolam; Neostigmine; Ondansetron; Propofol; Sevoflurane; Sodium Chloride; Adult; Analgesia; Article; Cholecystectomy; Clinical Trial; Controlled Clinical Trial; Controlled Study; Diastolic Blood Pressure; Double Blind Procedure; Drug Efficacy; Evaluation; Heart Rate; Human; Major Clinical Study; Pain; Premedication; Rating Scale; Scoring System; Statistical Significance; Systolic Blood Pressure; Time; Treatment Outcome
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
31
Sayı
2
