Diffusely Increased Splenic Fluorodeoxyglucose Uptake in Lung Cancer Patients

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dc.authoridAktas, Gul Ege/0000-0003-4880-2275
dc.authoridSoyluoglu, Selin/0000-0003-4473-7138
dc.authorwosidAktas, Gul Ege/R-1776-2019
dc.contributor.authorAktas, Gul Ege
dc.contributor.authorSarikaya, Ali
dc.contributor.authorDemir, Selin Soyluoglu
dc.date.accessioned2024-06-12T11:15:32Z
dc.date.available2024-06-12T11:15:32Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES: This study aimed to investigate the association of diffuse splenic F-18 fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) with tumor maximum standardized uptake value (SUVmax), presence of distant metastases, and hematological and inflammatory parameters. MATERIAL AND METHODS: Initial FDG PET/CT of 15 lung cancer patients with diffuse splenic FDG uptake were retrospectively analyzed (Group 1). Twelve patients who recently underwent FDG PET/CT for histopathologically proven lung cancer were enrolled as the control group (Group 2). All 27 patients had hematological data, including C-reactive protein (CRP) level, within 5 days before or after PET/CT. To determine SUVmax, the region of interests included the tumor, liver, spleen, and iliac crest. The possible associations between the spleen/liver (S/L) and bone marrow/liver (BM/L) ratios and tumor SUVmax, presence of metastasis, and hematological parameters were evaluated. RESULTS: The S/L ratio and hemoglobin (Hb) levels were different between the two groups (p=0.000 and 0.05, respectively). The number of patients with anemia were significantly higher in Group 1 than in Group 2 (p=0.02). Although mean Hb levels were different between the two groups, there was no correlation between Hb levels and S/L ratios. There was no significant difference between the two groups with respect to the numbers of patients who had an accompanying infection site. Only CRP levels were correlated with S/L ratios in Group 1 among various other parameters (r=0.559, p=0.05). CONCLUSION: Our results suggested that inflammation degree correlated with increased splenic FDG uptake in lung cancer patients and was enhanced by anemia. Systemic inflammation and anemia could be important causes of diffusely increased splenic FDG accumulation on PET/CT examinations of lung cancer patients.en_US
dc.identifier.doi10.5152/TurkThoracJ.2017.16025
dc.identifier.endpage10en_US
dc.identifier.issn1302-7808
dc.identifier.issn1308-5387
dc.identifier.issue1en_US
dc.identifier.pmid29404150en_US
dc.identifier.scopus2-s2.0-85042930724en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6en_US
dc.identifier.trdizinid236474en_US
dc.identifier.urihttps://doi.org/10.5152/TurkThoracJ.2017.16025
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/236474
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23974
dc.identifier.volume18en_US
dc.identifier.wosWOS:000396459800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBilimsel Tip Publishing Houseen_US
dc.relation.ispartofTurkish Thoracic Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpleenen_US
dc.subjectAnemiaen_US
dc.subjectInflammationen_US
dc.subjectLung Canceren_US
dc.subjectFluorodeoxyglucoseen_US
dc.subjectPositron Emission Tomographyen_US
dc.subjectBone-Marrowen_US
dc.subjectAnemiaen_US
dc.titleDiffusely Increased Splenic Fluorodeoxyglucose Uptake in Lung Cancer Patientsen_US
dc.typeArticleen_US

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