Role of quercetin in cadmium-induced oxidative stress, testicular damage, and apoptosis in rats
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Science Printers and Publishers Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The aim of this study was to investigate the role of quercetin on cadmium-induced oxidative stress, testicular damage, and apoptosis in rat testes. STUDY DESIGN: The rats were randomly allotted into 1 of 3 experimental groups: control, cadmium-treated, and cadmium-treated with quercetin; each group contained 10 animals. Control animals received daily injections of the saline vehicle alone. The cadmium-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 mL/kg/ day for 30 days, resulting in a dosage of 1 mg/kg cadmium. The rats in quercetin-treated groups were given quercetin (15 mg/kg body weight) once a day i.p., starting 2 days prior to the cadmium injection during the study period. All animals were sacrificed and testes tissues were removed for histopathological and biochemical (malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], and serum testosterone levels) investigation. RESULTS: The mean seminiferous tubule diameter, Johnsen's mean testicular biopsy score values, biochemical parameters (MDA, SOD, GSH-Px, and serum testosterone levels), and amount of germ cell apoptosis were significantly decreased in the cadmium-treated groups as compared to the control group. Furthermore, the quercetin-treated animals showed improved histological and biochemical parameters in the cadmium-treated group. CONCLUSION: The present study showed that quercetin treatment protected testes against toxic effects of cadmium. We believe that further preclinical research into the utility of quercetin may indicate its usefulness as a potential treatment for spermatogenesis after testicular injury caused by cadmium-treated rats. © 2016 Science Printers and Publishers, Inc.
Açıklama
Anahtar Kelimeler
3,3',4',5,7-Pentahydroxyflavone; Antioxidants; Apoptosis; Cadmium; Cadmium Poisoning; Oxygenradicals; Quercetin; Reactive Oxygen Species; Testes; Testicles; Testis; Testosterone, Cadmium Chloride; Glutathione Peroxidase; Malonaldehyde; Quercetin; Superoxide Dismutase; Testosterone; Quercetin; Cadmium; Glutathione Peroxidase; Malonaldehyde; Quercetin; Superoxide Dismutase; Animal Experiment; Animal Model; Animal Tissue; Apoptosis; Article; Biochemical Analysis; Controlled Study; Enzyme Blood Level; Germ Cell; Histopathology; Male; Nonhuman; Oxidative Stress; Priority Journal; Rat; Seminiferous Tubule; Testis Biopsy; Testis Injury; Testosterone Blood Level; Animal Cell; Antioxidant Activity; Enzyme Activity; Spermatogenesis; Testis Injury; Testis Size; Animal; Apoptosis; Drug Effects; Human; Metabolism; Oxidative Stress; Pathology; Testis; Animals; Apoptosis; Cadmium; Glutathione Peroxidase; Humans; Male; Malondialdehyde; Oxidative Stress; Quercetin; Rats; Seminiferous Tubules; Superoxide Dismutase; Testis
Kaynak
Analytical and Quantitative Cytology and Histology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
38
Sayı
1
