Preparation and Characterization of Chitosan/?-Carrageenan Based Polymeric Nanoparticles for Gemcitabine Delivery

Basit Öğe Kaydı
dc.contributor.authorYılmaz, Habibe
dc.date.accessioned2024-06-12T10:04:11Z
dc.date.available2024-06-12T10:04:11Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCancer is the most fatal disease of the last century after cardiovascular disease. Gemcitabine is a nucleosideanalogue used in the treatment of cancer. However, like many anticancer drugs, it has many side effects thatlimit treatment. A nano drug delivery system has been developed to provide effective treatment by reducingside effects. Chitosan and ?-carrageenan, which are regarded as safe by the FDA, were used in the preparationof the nano drug delivery system. In the synthesis, pre-ionic gelation followed by polyelectrolyte complexationmethod was used and then a second ionic gelation step was added. Chitosan: ?-carrageenan ratio and CaCl2concentration were optimized and the optimum polymer ratio was determined as 6:1 and CaCl2 concentrationwas 2.5%. Its hydrodynamic size at optimum conditions was 393 nm and its size measured size in TEM was 20nm. FTIR analyzes showed that nanoparticle synthesis was successful. Drug loading was performed byencapsulation and 58% drug loading was achieved. After drug loading, the hydrodynamic dimension wasincreased to 595 nm and its size measured size in TEM 45 nm. Drug release was monitored for 95 hours andwas determined to be higher at pH 6.0 compared to 7.4 and pH sensitive. In addition, the Higuchi model is themost suitable mathematical model for drug release kinetics. The obtained results showed that chitosan: ?carrageenan nanoparticles were suitable for gemcitabine delivery and were pH sensitive enough to respond tothe tumor microenvironment.en_US
dc.identifier.doi10.18185/erzifbed.1134093
dc.identifier.endpage648en_US
dc.identifier.issn1307-9085
dc.identifier.issn2149-4584
dc.identifier.issue2en_US
dc.identifier.startpage636en_US
dc.identifier.trdizinid1161380en_US]
dc.identifier.urihttps://doi.org/10.18185/erzifbed.1134093
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1161380
dc.identifier.urihttps://hdl.handle.net/20.500.14551/12695
dc.identifier.volume15en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePreparation and Characterization of Chitosan/?-Carrageenan Based Polymeric Nanoparticles for Gemcitabine Deliveryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu