Ameliorative effects of melatonin on intestinal oxidative damage in streptozotocin-induced diabetic rats

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dc.authoridYakut, Zatiye Ayça Çevikelli/0000-0002-6697-6781
dc.authoridŞener, Göksel/0000-0001-7444-6193
dc.authorwosidYakut, Zatiye Ayça Çevikelli/AAF-7800-2021
dc.authorwosidŞener, Göksel/AAN-4461-2021
dc.contributor.authorYakut, Zatiye Ayca Cevikelli
dc.contributor.authorAkcay, Gizem Buse
dc.contributor.authorCevik, Ozge
dc.contributor.authorSener, Goksel
dc.date.accessioned2024-06-12T10:59:25Z
dc.date.available2024-06-12T10:59:25Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Aims: The potential therapeutic effects of melatonin on changes in intestinal tissue of diabetic rats were investigated. Methods: Male Sprague-Dawley rats were assigned into 5 groups (10 rats in each): Control, diabetes, diabetes+insulin, diabetes+melatonin, and diabetes+insulin+melatonin groups. Streptozotocin (60 mg/kg) was administered intraperitoneally to the rats to induce diabetes. At the end of 8 weeks of treatment, after blood glucose measurement and subsequent decapitation, glutathione (GSH) and matondialdehyde (MDA) levels and caspase-3, myeloperoxidase (MPO), and superoxide dismutase (SOD) activities in the intestinal tissue were investigated. Results: in diabetic animals, elevated blood glucose levels caused oxidant damage in the intestinal tissue that was demonstrated with increased MDA levels, caspase and MPO activities, and decreased GSH levels and SOD activities. Although melatonin demonstrated more significant results than insulin, separate administration of both melatonin and insulin improved the oxidative damage parameters compared to the diabetes group. In the combined treatment group, all parameters were back to control levels statistically more significant when compared with the treatment-alone. Conclusion: Melatonin has been shown to protect intestinal tissue from diabetic oxidant damage. With insulin treatment in type I diabetes, melatonin supplements may increase the quality of life through reducing complications.en_US
dc.description.sponsorshipMarmara University Scientific Research Porejects Committee [SAG-CYLP-091215-0532]en_US
dc.description.sponsorshipThis study was supported by Marmara University Scientific Research Porejects Committee (Grant number: SAG-CYLP-091215-0532).en_US
dc.identifier.doi10.26650/IstanbulJPharm.2020.0078
dc.identifier.endpage167en_US
dc.identifier.issn2587-2087
dc.identifier.issue3en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2020.0078
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20442
dc.identifier.volume50en_US
dc.identifier.wosWOS:000605357000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal Of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectOxidative Damageen_US
dc.subjectIntestineen_US
dc.subjectInsulinen_US
dc.subjectMelatoninen_US
dc.subjectSuperoxide-Dismutase Activityen_US
dc.subjectCaspase-3 Activityen_US
dc.subjectStressen_US
dc.subjectInflammationen_US
dc.subjectParametersen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectActivationen_US
dc.subjectTissueen_US
dc.subjectModelen_US
dc.subjectZincen_US
dc.titleAmeliorative effects of melatonin on intestinal oxidative damage in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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