The only effects of recombinant follicle-stimulating hormone for ovulation induction in the pre-implantation period of rats

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dc.authorscopusid22950224600
dc.authorscopusid54684368800
dc.authorscopusid57218851601
dc.authorscopusid23100936100
dc.authorscopusid6701899425
dc.contributor.authorCanda M.T.
dc.contributor.authorKucuk M.
dc.contributor.authorBagriyanik H.A.
dc.contributor.authorOzyurt D.
dc.contributor.authorCanda T.
dc.date.accessioned2024-06-12T10:24:57Z
dc.date.available2024-06-12T10:24:57Z
dc.date.issued2007
dc.description.abstractObjective: The aim of this study was to evaluate the changes in follicular development, serum hormonal levels, and endometrium in the pre-implantation period of rats by using recombinant FSH (rFSH) without human chorionic gonadotropin (hCG). Methods: Thirty female rats were studied in six groups of five specimens. Two groups determined as controls (groups 1 and 2). Two groups received constant doses of rFSH (groups 3 and 4) and other two decreasing doses (groups 5 and 6). One of the paired groups was mated. Uterus, ovaries, and blood samples were taken from non-mated groups (groups 1, 3, and 5) at the proestrus period and from mated groups (groups 2, 4, and 6) in the pre-implantation period. Results: In non-mated groups antral follicles and corpus luteum periodicum and in mated groups antral follicles, corpus luteum periodicum, and corpus luteum graviditatis were increased in rFSH groups, especially in decreasing dose groups. Estradiol (E2) levels were increased and progesterone (P)/E2 ratio was significantly decreased in decreasing dose groups. Endometrium surface epithelium was columnar, irregular, and folded in rFSH groups. Endometrium glandular epithelium was cuboidal in all groups. In decreasing dose groups endometrial stroma was smooth and fibroblastic. Mitotic indices of endometrium surface, glandular epithelium, and stroma were significantly decreased in rFSH groups. Primary follicles and P levels showed no change. Conclusion: It seems likely that decreasing doses of rFSH might be used in order to improve follicular development, although it has negative effects with E2 on endometrium in the pre-implantation period of rats. © 2006 Springer-Verlag.en_US
dc.identifier.doi10.1007/s00404-006-0236-x
dc.identifier.endpage105en_US
dc.identifier.issn0932-0067
dc.identifier.issue2en_US
dc.identifier.pmid16953427en_US
dc.identifier.scopus2-s2.0-33847642170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-006-0236-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16106
dc.identifier.volume275en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrium; Fsh; Hcg; Ovary; Ovulation Inductionen_US
dc.subjectChorionic Gonadotropin; Estradiol; Progesterone; Recombinant Follitropin; Animal Experiment; Article; Blood Sampling; Controlled Study; Corpus Luteum; Endometrium; Female; Fibroblast; Follicular Phase; Hormone Blood Level; Mitosis Index; Nonhuman; Ovary; Ovary Follicle Cell; Ovulation Induction; Preimplantation Embryo; Proestrus; Rat; Uterus; Animals; Dose-Response Relationship, Drug; Endometrium; Female; Follicle Stimulating Hormone; Follicular Phase; Ovary; Ovulation Induction; Rats; Rats, Wistar; Recombinant Proteinsen_US
dc.titleThe only effects of recombinant follicle-stimulating hormone for ovulation induction in the pre-implantation period of ratsen_US
dc.typeArticleen_US

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