The role of native vitamin D treatment in the clinical assessment of osteoporosis in patients with chronic kidney disease
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
State Institution Institute of Nephrology of the National Academy of Medical Science of Ukraine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The prevalence of vitamin D deficiency is high in patients with chronic kidney disease (CKD). Vitamin D deficiency is associated with various bone disorders such as osteoporosisbyaffectingbonemineralization. Currentinternationalguidelinesrecommend vitamin D supplementation in CKD as well as in the general population. However, the effect of various forms of vitamin D on bone health in CKD remains unclear. Few randomized controlled studies have evaluated the effects of vitamin D supplementation on bone mineral density and bone turnover markers; however, the findings of these studies are heterogeneous. This review aimed to present comprehensive and current findings on the effects of native vitamin D supplementation on bone biomarkers and bone mineral density in CKD. We infered that native vitamin D treatment could improve some bone biomarkers, particularly in predialysis CKD patients with severe vitamin D deficiency. Our findings also draw attention to the fact that vitamin D is an important factor in treatment. However, it is essential to design better-quality and comprehensive controlled studies to obtain clear findings. © S. Demirel, M. Gürbüz, 2024.
Açıklama
Anahtar Kelimeler
Calcidiol; Calcitriol; Osteoporosis; Renal Osteodystrophy; Vitamin D
Kaynak
Ukrainian Journal of Nephrology and Dialysis
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
81
Sayı
1
